Cancer Clinical Research
This is a listing of Loyola University Health System Cancer clinical research that is open and actively recruiting patients. Please click on the name of the research for a brief description, eligibility requirements and contact information. All research listed below have been approved by Loyola's Institutional Review Board chairman for promotion on our Web site.
For more information call (888) LUHS-888.
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Cancer
A Study to Compare Radiotherapy Alone Versus Radiotherapy with Concurrent Chemotherapy (with the drug temozolomide) Versus Radiotherapy with Adjuvant Chemotherapy Versus Radiotherapy with Concurrent and Adjuvant Chemotherapy.
The purpose of this study is to determine whether the addition of temozolomide treatment to radiotherapy (concomitant treatment) or the addition of temozolomide treatment after completion of radiotherapy on five days out of every 28 days for 12 months (adjuvant treatment) will improve the results of the treatment. This study will find out what effects, good and/or bad, the addition of temozolomide has when it is given at the same time as radiotherapy, after radiotherapy or both.
Evaluation of Unlicensed Cord Blood Units in Pediatric and Adult Patients
To provide access to cord blood for those recipients whose best choice for cord blood does not meet all FDA standards but does meet study standards set by the National Marrow Donor Program. This study will assess how well and how quickly recipients’ blood counts return to normal after transplant.
Ezatiostat hydrochloride in individuals with lenalidomide refractory or resistant myelodysplastic syndrome (MDS)
The overall purpose of this study is to find out what the effects, good and/or bad, ezatiostat hydrochloride treatment has on you and your type of MDS.
Steroids plus ALD518 vs. Steroids Alone after Allogeneic Stem Cell Transplant for Participants with Acute GVHD (Graft vs. Host Disease).
The purpose of this trial is to test the good and bad effects of ALD518 at differing dose levels in two groups of participants with acute graft vs. host disease.
Treatment Therapy Followed by Umbilical Cord Stem Cell Transplant
The primary objective of this study is to measure progression free survival in the elderly at three years after umbilical cord stem cell transplantation, which may include an expanded umbilical cord stem cell unit and using pre-transplant conditioning of fludarabine, cyclophosphamide and total body irradiation.
Vaccine Study for the Prevention of Shingles in Individuals with Cancer
The purpose of this study is to test the safety, tolerability and effectiveness of the vaccine, V212, on participants with cancer.
Cancer: Bladder
A Comparison of Comparing the Effects, Good and/or Bad, of a Standard Lymph Node Removal Versus an Extended Lymph Node Removal for Participants with Bladder Cancer.
The purpose of this study is to compare the effects, good and/or bad, of performing a standard lymph node removal versus an extended lymph node removal.
Comparison of open radical cystectomy and robotic-assisted radical cystectomy in participants with bladder cancer.
The purpose of this study is to compare the recovery times of two different surgical methods for radical cystectomy. The study will compare an open surgical method to a robotic-assisted surgery.
Cancer: Bladder and Urinary
A Study Comparing the Combination of Gemcitabine, Cisplatin and Bevacizumab on Transitional Cell Carcinoma of the Urinary Tract
The purpose of this study is to see what effects, good and/or bad, the combination of gemcitabine, cisplatin and bevacizumab has on participants and their cancer.
Cancer: Bone
Bone Health in the Jaw of Cancer Patients
The purpose of this study is to learn how often ONJ occurs in participants who cancer has spread to the bone and are being treated with zoledronic acid during a three-year time period after starting treatment. This study will also identify risk factors associated with ONJ.
Cancer: Breast
A Comparison Study of Two Radiation Therapies for Early-Stage Breast Cancer: A Brief Treatment Period at Higher Dose vs. Standard Dose over Longer Treatment Period.
The purpose of this study is to compare two approaches to radiation therapy: One therapy would entail a higher daily dose during the course of three weeks with a boost given on each day of radiation therapy. The other therapy would entail standard whole breast radiation followed by a boost given on separate days extending over the course of six to seven weeks.
A Comparison Study ofTo compare the Effects of the Nutritional Supplement Omega-3 Fatty Acid against a Placebo on the Joint Pain and Stiffness that is Associated with Taking Aromatase Inhibitors in Women with Breast Cancer
The purpose of this study is to compare the effects, good and/or bad, of the nutritional supplement omega-3 fatty acid against a placebo (contains no active ingredient) on joint pain and stiffness that is associated with taking aromatase inhibitors.
A Comparison of Two Different Treatments for Participants with HER2- positive Breast Cancer.
This trial will compare which of two treatments is most effective for participants with HER2- breast cancer.
A Study to Determine if Vitamin D Reduces the Thickness of Breast Tissue on a Mammogram and Breast Cell Growth.
The purpose of this study is to see if vitamin D affects breast tissue by reducing tissue thickness (the amount of glandular breast tissue compared to fat) on a mammogram (a special imaging exam of the breast that uses X-rays) and if it reduces the growth of breast cells.
A randomized phase III study of whole breast radiation versus partial breast radiation for women with breast cancer
The purpose of this study is to see if partial breast irradiation is as good as or better than whole breast irradiation in keeping cancer from coming back in the breast.
Comparing Different Chemotherapy Regimens to Treat Breast Cancer Before Having Surgery
The purpose of this study is to compare different chemotherapy treatments and determine which is better for breast cancer patients.
Comparing Standard Endocrine Therapy and Chemotherapy in Women with Hormone-responsive Breast Cancer
The purpose of this study is to find out if the recurrence score can help decide whether participants should receive chemotherapy or not.
Comparing the Effects of Trastuzumab Emtansine With Currently Available Treatments for HER2-Positive Locally Advanced or Metastatic Breast Cancer
The purpose of this study is to compare the effects, good and/or bad, of trastuzumab emtansine (previously known as T-DM1) with currently available treatments on you and your breast cancer to find out which therapy is better. In this study, you will receive either trastuzumab emtansine or the treatment regimen of your study physician’s choice (TPC).
Comparison of Metformin and Placebo on Recurrence and Survival in Breast Cancer
The purpose of this study is to find out whether it is better to receive the drug Metformin with the usual treatment for breast cancer or not.
Comparison of Standard Chemotherapy and Standard Chemotherapy with Investigational Drugs
The purpose of this study is to determine how women with breast cancer will respond to standard chemotherapy versus standard chemotherapy with investigational drugs.
Comparison of Surgery Plus Radiation Versus the Standard Approach of Continued Treatment with Medication in Individuals with Metastatic Breast Cancer
The purpose of this study is to compare the good and/or bad effects of a new approach that includes surgery plus radiation for the tumor in your breast to the standard approach of continued treatment with medication.
Pathological Studies on Breast Cancer Tissue
The purpose of the study is to analyze tumor specimens from breast cancer participants.
Study Comparing Radiation Therapy With or Without Trastuzumab in Women With Early Stage Breast Cancer
This purpose of this study is to find out if adding trastuzumab to breast radiation therapy is more effective than radiation therapy without trastuzumab in preventing occurrence of breast cancer in the same breast, in the other breast or in other parts of the body in patients with early stage breast cancer.
Study Using Two Investigational Drugs for Individuals with Breast Cancer who have Progressed while Receiving Prior Therapy
The purpose of this study is to determine how safe and tolerable this combination of the two investigational drugs is in certain individuals with breast cancer. This extension study is designed to allow individuals who are benefitting from the combination to continue their treatment.
Study to Evaluate Fatigue in Participants in the NCIC CTG MA.32 Trial
To evaluate fatigue in participants in the NCIC CTG MA.32 trial.
The Effects of Trastuzumab on Standard Treatment with Chemotherapy for Early Stage, HER2-low Breast Cancer
The main purpose of this study is to learn if adding a targeted therapy, trastuzumab, to standard treatment with chemotherapy for early stage, HER2-low breast cancer, will prevent breast cancer from returning.
Cancer: Cervical
Study Comparing Standard Radiation Therapy Treatment to an Investigational Treatment of Radiation Therapy Combined with Chemotherapy in Patients with Cervical Cancer
The purpose of this study is to determine if the investigational treatment is better than the standard treatment.
Cancer: Colon
Chemotherapy in Individuals with Advanced Colon Cancer
This study is being conducted to evaluate the effects (good and bad) of different chemotherapy treatments. One of the common combinations of chemotherapy drugs used to treat colon cancer includes 5-fluorouracil (also called 5-FU), leucovorin and oxaliplatin, and is called “FOLFOX.” At the present time, the Food and Drug Administration (FDA) has approved each of these drugs as treatment for colon cancer. FOLFOX is a standard treatment used to prevent colon cancer from coming back (recurrence).
Cancer: Colorectal
The Study of mFOLFOX7 or XELOX Plus Bevacizumab Versus
5-Fluorouracil/Leucovorin or Capecitabine Plus Bevacizumab in Individuals 70 Years of Age or Older with Colorectal Cancer
The purpose of this research study is to compare the length of time during and after treatment that metastatic colorectal cancer does not get worse in older patients treated with bevacizumab plus either 5-fluorouracil/leucovorin or capecitabine without oxaliplatin, or in patients treated with bevacizumab plus 5-fluorouracil/leucovorin or capecitabine with oxaliplatin. All of the study drugs have been FDA-approved for the treatment of metastatic colorectal cancer.
The study of medications in participants with previously untreated colorectal cancer.
The purpose of this study is to learn if certain levels of biomarkers (for example, ERCC-1 as a marker for chemotherapy resistance and VEGF-A as a marker for a response to bevacizumab) can be used to determine how well colorectal cancer will respond to bevacizumab plus mFOLFOX6 or FOLFIRI by changes in how genes and proteins are regulated in response to bevacizumab or chemotherapy. A biomarker is measured and evaluated using blood and/or tissue.
Cancer: Esophageal
A Study to Evaluate the Addition of the Study Drug Cetuximab to the Standard Therapy Regimen for Esophageal Cancer Patients Who Are Treated Without Surgery.
The purpose of this study is to see if adding the study drug cetuximab to the standard treatment drugs paclitaxel and cisplatin, along with radiation therapy, will improve overall survival for individuals with esophageal cancer who are unable to have surgery, or choose not to have surgery.
The Study of Adding the Drug Trastuzumab to the Standard Chemotherapy and Radiation Therapy Plan for Individuals with Esophageal Cancer
The purpose of this study is to determine whether the addition of the drug trastuzumab to the standard treatment regimen for esophageal cancer can help prevent your cancer from growing back.
Cancer: Gallbladder or Bile Duct
Chemotherapy and Radiation for Participants With Cancer in the Bile Duct or Gallbladder
The purpose of this study is to find out what effects, good and/or bad, capecitabine, gemcitabine and radiation have on you and your cancer of the bile duct or gallbladder.
Cancer: Gastric or Gastroesophageal Jct
The Study of MK-2206 in Individuals with Gastric or Gastroesophageal Junction (GEJ) Cancer that has Worsened or Returned after Treatment
The purpose of this study is to find out what effects, good and/or bad, MK-2206 has on you and your gastric or gastroesophageal junction (GEJ) cancer. MK-2206 is an investigational drug that has not been approved by the FDA for use in this type of cancer.
Cancer: Glioblastoma
The Study of an Investigational Medication in Patients With Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma.
The purpose of this research study is to find out the good and bad effects of adding an investigational vaccine, rindopepimut (also known as CDX-110), to the chemotherapy drug called temozolomide in patients with brain tumors.
Cancer: Head and Neck
A Study of Radiation Therapy Plus or Minus the Drug Cetuximab in the Treatment of Head and Neck Cancer.
The purpose of this study is to compare the effects, good and/or bad, of radiation therapy alone with radiation therapy and cetuximab on you and your cancer. In this study, you will receive either radiation therapy alone or radiation therapy and cetuximab.
Chemotherapy in Patients With Recurrent Head and Neck Cancer
The purpose of this study is to compare the effects (good and bad) of the addition of bevacizumab to standard chemotherapy (cisplatin and docetaxel or cisplatin and 5-FU) and to determine if the combination of standard chemotherapy and bevacizumab can increase the effectiveness of treatment for head and neck cancer. This combination is experimental.
The study of radiation therapy plus the drug cetuximab versus radiation therapy plus the drug cisplatin for the treatment of HPV-associated oropharynx cancer.
The purpose of this study is to compare the effects, good and/or bad, of two standard treatments for head and neck cancer: radiation therapy and cisplatin or radiation therapy and cetuximab. The two treatments may be comparable in treating your cancer, but radiation and cetuximab may result in less severe side effects.
Cancer: Kidney
A Comparison of Everolimus Alone Versus the Combination of Everolimus and Bevacizumab for Advanced Kidney Cancer
The purpose of this study is to compare the effects of a drug called everolimus alone with those of the combination of everolimus and a drug called bevacizumab for advanced kidney cancer to find out which is better. In this study, you will get either the combination of everolimus and a placebo or the combination of everolimus and bevacizumab.
Cancer: Kidney (Renal)
Chemotherapy in Patients Who Have Cancer of the Kidney That Has Spread to Other Organs of the Body
The purpose of this study is to compare the safety and effectiveness of the study drug Everolimus given before sunitinib versus sunitinib given before the study drug Everolimus, to determine the most effective order to give sunitinib and Everolimus to slow tumor growth and to determine which study treatment schedule has less side-effects.
The Study of a Commercial Medication in Individuals with Kidney Cancer
The purpose of this study is to see whether treatment with everolimus after surgery for kidney cancer will increase the time without cancer returning.
Cancer: Leukemia
A Randomized Study Comparing the Placebo or Study Drug Plus the Standard Medication that is Used to Prevent Moderate to Severe Chronic Graft Vs. Host Disease in Adult Participants with Acute Myeloid Leukemia, Acute Lymphoid Leukemia or Myelodysplastic Syndrome after Allogeneic Stem Cell Transplantation from Unrelated Donors.
The primary reason for this study is to test the effect of the study drug or placebo when combined with the standard preventive drugs for Graft Vs. Host Disease (GVHD).
A Study Combining Epratuzumab with Cytarabine and Clofarabine for Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)
The purpose of this study is to test the effects of combining clofarabine, cytarabine and epratuzumab on precursor B-cell acute lymphoblastic leukemia.
A Study Evaluating the Safety and Efficacy of Combining Two Drugs for Participants Age 60 and Older on Previously Untreated Acute Myeloid Leukemia
The purpose of this study is to find out the safety and efficacy of combining two drugs, azacitidine and gemtuzumab ozogamicin, to treat participants age 60 or older for untreated acute myeloid leukemia.
A Study Investigating the Addition of Pravastatin to Chemotherapy for the Treatment of Relapsed Acute Myelogenous Leukemia
The purpose of this study is to see what effects, good and/or bad, that adding pravastatin, a drug usually used to treat high cholesterol, to chemotherapy has on relapsed acute myelogenous leukemia.
A Study of the Combination of Chemotherapy and Dasatinib with or without Stem Cell Transplant on Acute Lymphoblastic Leukemia
The purpose of this study is to find out what effects, good and/or bad, the investigational drug dasatinib has on you and your leukemia.
Leukemia Relapse Trial
The purpose of this study is to determine patient outcomes following high-dose combination chemotherapy treatment and to compare higher versus standard dose vincristine chemotherapy.
Risk-adapted Chemotherapy in Younger Patients with Newly Diagnosed Standard-risk Acute Lymphoblastic Leukemia
Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy), giving the drugs in different doses, and giving the drugs in different combinations may kill more cancer cells. Children will be placed in groups according to the results of biology testing done on the child’s bone marrow. According to these studies, the low-risk children get less intense treatment, and the higher-risk children will be treated on a high-risk study.
Treatment with Clofarabine in Newly Diagnosed Acute Myeloid Leukemia in Adults Ages 60 Years or Older
The purpose of the study is to compare the effect of clofarabine versus standard therapy in newly diagnosed acute myeloid leukemia (AML) patients who are 60 years of age or older.
Cancer: Liver
Ramp-up Sorafenib Trial
The main purpose of this study is to see if subjects can tolerate treatment better if they start taking smaller doses of sorafenib and then gradually increase their dose to two tablets twice a day.
The Study of Sorafenib and Chemotherapy in Individuals Who Have Liver Cancer (Hepatocellular Carcinoma) That is Not Removable by Surgery and the Cancer Has Not Spread Outside the Liver
The purpose of this study is to see if adding the oral chemotherapy pill, sorafenib, to localized chemotherapy (chemoembolization) to the liver will help individuals to live longer than treatment with localized chemotherapy to the liver without sorafenib.
Cancer: Lung
Additional Chemotherapy Drug after surgical removal of Non Small Cell Lung Cancer
The purpose of this study is to determine if adding the new drug bevacizumab to chemotherapy improves the chance for cure for patients who have had surgery for the removal of the lung cancer and to compare the effects (good and bad) of adding bevacizumab to chemotherapy compared to standard chemotherapy alone. Bevacizumab works by preventing the formation of new blood vessels, including those that surround and supply cancer cells, with the oxygen and nutrients they need to survive and grow.
Chemotherapy in Individuals With Lung Cancer
The primary objective of this study is in patients with advanced NSCLC treated with carboplatin, paclitaxel and bevacizumab (if appropriate) with or without cetuximab, to compare overall survival (OS) in the entire study population; progression-free survival (PFS) by institutional review in EGFR FISH-positive patients. The secondary objectives are in patients with advanced NSCLC treated with carboplatin, paclitaxel and bevacizumab (if appropriate) with or without cetuximab, to compare OS and PFS by centralized review in EGFR FISH-positive patients; PFS by centralized image review and by institutional review in the entire study population. To compare the response rate (confirmed plus unconfirmed, complete and partial responses) in the subset of patients with measurable disease in EGFR FISH-positive patients; the entire study population. The purpose of this study is to compare the effects, good and/or bad, of cetuximab on lung cancer.
Pazopanib & weekly Paclitaxel Chemotherapy in Patients With Advanced Lung Cancer
The purpose of this study is to learn about the good and bad effects of pazopanib when it is given with a chemotherapy drug called paclitaxel to treat advanced lung cancer.
Cancer: Lymphoma
A Randomized Study Using RAD001 Adjuvant Therapy Versus Placebo in Patients With Diffuse Large B-cell Lymphoma Who Have Achieved Complete Reponse With First-line Rituximab-chemotherapy
The purpose of this study is to learn if the study drug RAD001 can slow or prevent the recurrence of your cancer compared to a placebo.
A Randomized Study for Untreated Mantle Cell Lymphoma Patients 65 Years Old or Under With Treatment of Either R-HCVAD/MTX/Ara-C Chemotherapy With an Autologous Stem Cell or R-Bendamustine Chemotherapy With an Autologous Stem Cell Transplant.
The purpose of this study is find out what effects, good and/or bad, a combination of drugs called “R-HCVAD/MTX/ARA-C” compared to “R-bendamustine” followed by a stem cell transplant has on mantle cell lymphoma.
A Study Combining Vorinostat with Rituximab, Cyclophosphamide, Doxorubicin, Prednisone and Vincristine
The purpose of this study is to determine the safety, effectiveness and maximum tolerated dose of vorinostat in combination with rituximab, cyclophosphamide, doxorubicin, prednisone and vincristine.
Chemotherapy Treatments for Diffuse Large B-cell Lymphoma.
The purpose of this study is to compare the effects (good and bad) of two treatments for lymphoma. The treatments are known as R-CHOP and DA-EPOCH-R. Another goal of the study is to analyze your tumor using new scientific laboratory studies to better understand your type of lymphoma.
Medication Study for Relapsed Hodgkins Lymphoma
This study is for people with relapsed or refractory Hodgkins lymphoma. The purpose is to see what effects (good and bad) a drug called temsirolimus has on you and your lymphoma.
Treatment Therapy Followed by Stem Cell Transplant for Relapsed Follicular Non-Hodgkin’s Lymphoma
The primary objective of this study is to measure progression-free survival at two years after allogeneic hematopoietic stem cell transplantation (HSCT) using pre-transplant conditioning of fludarabine, cyclophosphamide and rituximab (FCR) for patients with relapsed follicular non-Hodgkin’s lymphoma.
Treatment Therapy for Hodgkin’s Lymphoma Patients With Disease Present After an Autologous Stem Cell Transplant
The primary objective of this study is to compare the progression-free survival of patients that have residual disease or disease that has not resolved using best supportive care with a placebo versus best supportive care with SGN-35.
Treatment Therapy to Mobilize and Collect Stem Cells for Autologous Stem Cell Transplant in Patients with Non-Hodgkin’s Lymphoma Weighing =154 lb
The primary objective of this study is to measure the number of stem cells collected for autologous stem cell transplant in patients with Non-Hodgkin’s lymphoma (NHL) using fixed dose of plerixafor in combination with G CSF as compared to the standard weight-based dose of plerixafor in combination with G CSF.
Treatment for Newly Diagnosed Hodgkin’s Lymphoma Based on PET Scan Results Following Two Cycles of Standard Treatment with ABVD Chemotherapy
The purpose of this study is to find out if we can determine the type of chemotherapy you may need to treat your Hodgkin’s lymphoma and whether or not you will need radiation therapy in addition to chemotherapy based on the results of your PET scan.
Treatment of Aggressive Hodgkin Lymphoma Based on PET Scan Results
This study will follow PET scan results to determine if your disease is responding to standard treatment for your Hodgkin lymphoma. If it is not responding, you will be switched to a more intensive treatment plan.
Treatment of Non-Hodgkins Lymphoma for Individuals Who Have Been Previously Treated or Who are Ineligible for or Have Previously Received an Autologous Stem Cell Transplant
The purpose of this study is to see if the study drug plus rituximab is safe and if it will stop your cancer from growing or cause your cancer to shrink.
Cancer: Lymphoma and Leukemia
Clinical trial researching an investigational drug for lymphoma patients
To evaluate the benefits of an investigational drug in patients with relapsed or refractory lymphoma
Cancer: Lymphoma, Leukemia
Umbilical Cord Blood Transplant Followed by Infusion at 24 Hours Post-Transplant of Blood Cells (Expanded Human Myeloid Progenitor Cells)
The purpose of this study is to measure the safety of ex vivo expanded human myeloid progenitor cells. Expanded human myeloid progenitor cells have the ability to make red blood cells, platelets and some kinds of white blood cells.
Cancer: Multiple Myeloma
A Study Combining Bendamustine with Bortezomib, Lenalidomide and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma
The purpose of this study is to determine the safety, effectiveness and maximum tolerated dose of bendamustine in combination with bortezomib, lenalidomide and dexamethasone.
High-dose Busulfan and Melphalan followed by Bortezomib (BuMelVel) as Chemotherapy prior to Autologous Stem Cell Transplantation for Multiple Myeloma
The purpose of this study is to evaluate the effectiveness of high-dose busulfan and melphalan followed by bortezomib as chemotherapy prior to autologous stem cell transplantation for individuals with multiple myeloma and to measure the level of cells in the blood in order to evaluate disease response.
Cancer: Pancreatic
Comparison of Erlotinib in Combination with Gemcitabine Versus Gemcitabine Alone in Individuals with Pancreatic Cancer that was Removed by Surgery
The purpose of this study is to compare the effects, good and/or bad, of the study drug erlotinib in combination with gemcitabine versus gemcitabine alone for individuals with pancreatic cancer that was removed by surgery.
The Study of Dendritic Cell Vaccine in Individuals who have Pancreatic Cancer that cannot be Surgically Removed
The purpose of this study is to determine the safety and effectiveness of this new two-part therapy. The radiation is typically given as a daily treatment Monday - Friday for four to five weeks, but in this study, it will be given as doses over a two-week period using only a high-dose strategy. Following this, a vaccine will be injected into your pancreatic tumor, under either ultrasound or CT-scan guidance as an experimental procedure, to see if we can shrink the tumor so that it can then be removed surgically. A secondary purpose of the research project is to see if the vaccine stimulates your immune system.
Cancer: Prostate
A Phase III Trial Comparing the Effectiveness of Three Treatment Methods
for Prostate Cancer in Individuals who have a Rising PSA after having a Radical Prostatectomy
The purpose of this study is to compare the effects of three treatment methods for men with prostate cancer who have a rising PSA after prostatectomy surgery. The three methods are: radiation to the prostate bed only, hormone therapy for four to six months plus radiation therapy to the prostate bed, or hormone therapy for four to six months plus radiation therapy to the prostate bed and to the pelvic lymph nodes.
A Study Comparing Hormone Therapy with or without IMC-A12 in Individuals with New Hormone-sensitive Metastatic Prostate Cancer
The purpose of this study is to find out what effects, good and/or bad, there are to adding IMC-A12 to standard hormone therapy (bicalutamide and goserelin acetate or leuprolide acetate).
A Study Comparing Radiation Therapy with or without Hormone Therapy for Individuals with Intermediate-risk Prostate Cancer.
The purpose of this study is to compare the effects of radiation therapy with or without hormone therapy on individuals with intermediate-risk prostate cancer.
A Study Comparing the Effects of Abiraterone Acetate Treatment with Hormone Therapy on Participants with Prostate Cancer.
The purpose of this study is to find out what effects, good and/or bad, abiraterone acetate has on you and your prostate cancer.
Cancer: Prostate Cancer
Study of Sipuleucel-T Therapy in Men with Advanced Prostate Cancer
The purpose of this study is to learn more about the occurrence of cerebrovascular events (more commonly known as “strokes”) reported during or following sipuleucel-T therapy, and about the survival of all study subjects.
Cancer: Rectal
A Combination of Chemotherapy (Including Cetuximab), Radiation Therapy and Surgery for Participants With Stage II or III Rectal Cancer
The purpose of this study is to find out what effects, good and/or bad, the combination of the chemotherapies, radiation therapy and surgery has on the participant and their rectal cancer.
Cancer: Renal and Melanoma
A Registry to Collect Information on Participants who have Metastatic Renal Cell Cancer or Metastatic Melanoma and are Currently Prescribed the Study Medication Interleukin-2
The main reason why this registry is being set up is to collect information on participants who are receiving treatment with Interleukin-2 in an organized way to learn more about patient care during and after treatment.
Cancer: Salivary Gland
A Study to Compare Radiation Therapy and Chemotherapy to Radiation Therapy Alone in Individuals Who Have Had Surgical Removal of a High-risk Salivary Gland Tumor.
This study will compare the effects, good and/or bad, of radiation and chemotherapy with radiation alone on your salivary gland cancer to find out which is better at reducing the chance that your cancer will come back.
Cancer: Skin
A Study to Determine which Participants with Melanoma Have a Better Response to a Study Medication and to Identify Markers that may Predict Response to IL-2.
The purpose of this study is to determine which participants with melanoma have a better response to IL-2 and to identify markers that may predict response to IL-2 by collecting participant information ( for example cancer diagnosis and history, prior treatments for cancer, etc.), blood and tumor samples prior to treatment and tumor measurements after treatment.
Study of an Investigational Medication in Individuals with Melanoma.
The purpose of this study is to compare the effects, good and/or bad, of ipilimumab with interferon alfa-2b on you and your melanoma to find out which is better.
Cancer: Uterine
Comparison of a Combination of Chemotherapy Drugs to the Standard Chemotherapy Treatment for Uterine Cancer
The purpose of this study is to compare a different chemotherapy combination with the current standard chemotherapy treatment for uterine cancer.
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Maintenance Therapy with Azacitadine and Valproic Acid after Allogeneic Stem Cell Transplant in Participants with High-Risk Acute Myelogenous Leukemia or Myelodysplastic Syndrome
The purpose of this research is to find out the good and bad effects of the combination of valproic acid and azacitadine in participants with with high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) after allogeneic stem cell transplant.
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