Charles Hemenway
  • Ronald McDonald House Charities Endowed Professor in Pediatric Oncology
  • Director, M.D./Ph.D. Program
  • Division Director, Pediatric Hematology/Oncology
  • Pediatric Hematology/Oncology
Cancer in Children and Adolescents, Bleeding Disorders in Children and Adolescents, Anemia in Children and Adolescents
Board Certifications
  • Pediatric Hematology-Oncology - Subspecialty Cert: AM Board of Pediatrics

Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation PotentialKuntimaddi,A.; Achille,N. J.; Thorpe,J.; Lokken,A. A.; Singh,R.; Hemenway,C. S.; Adli,M.; Zeleznik-Le,N. J.; Bushweller,J. H.Cell reports 2015 ;11(5):808-820

Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4Lokken,A. A.; Achille,N. J.; Chang,M. J.; Lin,J. J.; Kuntimaddi,A.; Leach,B. I.; Malik,B.; Nesbit,J. B.; Zhang,S.; Bushweller,J. H.; Zeleznik-Le,N. J.; Hemenway,C. S.Leukemia research 2014 ; ( ):

An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemiasBarretto,N. N.; Karahalios,D. S.; You,D.; Hemenway,C. S.Journal of experimental therapeutics & oncology 2014 ;10(4):293-300

CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3Malik,B.; Hemenway,C. S.FEBS letters 2013 ; ( ):

Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenesChang,M. J.; Wu,H.; Achille,N. J.; Reisenauer,M. R.; Chou,C. W.; Zeleznik-Le,N. J.; Hemenway,C. S.; Zhang,W.Cancer research 2010 ;70(24):10234-10242

Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression.Lin,J. J.; Hemenway,C. S.Journal of Biological Chemistry 2010 ;285(16):11966-11973

Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents.Bennett,C. A.; Winters,A. C.; Barretto,N. N.; Hemenway,C. S.Leukemia research 2009 ;33(7):937-947

The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells.Palermo,C. M.; Bennett,C. A.; Winters,A. C.; Hemenway,C. S.Leukemia research 2008 ;32(4):633-642

Hurricane Katrina's impact on pediatric and adult patients with sickle cell disease.Karras,N. A.; Hemenway,C. S.Journal of Health Care for the Poor & Underserved 2007 ;18(2):382-393

Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner.Zhang,W.; Xia,X.; Reisenauer,M. R.; Hemenway,C. S.; Kone,B. C.Journal of Biological Chemistry 2006 ;281(26):18059-18068

Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseasesReiser,J.; Zhang,X. Y.; Hemenway,C. S.; Mondal,D.; Pradhan,L.; La Russa,V. F.Expert Opinion on Biological Therapy 2005 ;5(12):1571-1584

MLL fusion partners AF4 and AF9 interact at subnuclear fociErfurth,F.; Hemenway,C. S.; de Erkenez,A. C.; Domer,P. H.Leukemia 2004 ;18(1):92-102

The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cellsSrinivasan,R. S.; Nesbit,J. B.; Marrero,L.; Erfurth,F.; LaRussa,V. F.; Hemenway,C. S.Leukemia 2004 ;18(8):1364-1372

The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressorSrinivasan,R. S.; de Erkenez,A. C.; Hemenway,C. S.Oncogene 2003 ;22(22):3395-3406

The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemiasHemenway,C. S.; de Erkenez,A. C.; Gould,G. C.Oncogene 2001 ;20(29):3798-3805

Identification and analysis of a third mouse Polycomb gene, MPc3Hemenway,C. S.; Halligan,B. W.; Gould,G. C.; Levy,L. S.Gene 2000 ;242(1-2):31-40

Medical School
  • University of Massachusetts Medical School
  • University of Florida, Internal Medicine & Pediatrics
  • Duke University Medical Center, Pediatrics: Pediatric Hematology-Oncology
  • French
  • Dogs
  • Hiking
  • Fishing
  • Skiing