CONTACT INFORMATION http://www.loyola.org
Christopher Wiethoff
Ph.D.
  • Assistant Professor
  • Microbiology and Immunology
Research Keywords
  • Antivirals
  • Asthma
  • Biophysics
  • Bronchitis Obliterans Syndrome (BOS)
  • fluorescence
  • Gene Therapy
  • Obliterative Bronchiolitis (OB)
  • Pulmonary Diseases
  • Reactive Oxygen Species
  • Vaccine
  • Heart
  • Infectious Diseases/Agents
  • Inflammation
  • Innate Immunity
  • Lung Fibrosis (IPF, UIP)
  • Membranes
Publications

Restriction of HIV-1 by rhesus TRIM5alpha is governed by alpha-helices in the Linker2 regionSastri,J.; Johnsen,L.; Smolin,N.; Imam,S.; Mukherjee,S.; Lukic,Z.; Brandariz-Nunez,A.; Robia,S. L.; Diaz-Griffero,F.; Wiethoff,C.; Campbell,E. M.Journal of virology 2014 ; ( ):

Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosisFreeman,D.; Cedillos,R.; Choyke,S.; Lukic,Z.; McGuire,K.; Marvin,S.; Burrage,A. M.; Sudholt,S.; Rana,A.; O'Connor,C.; Wiethoff,C. M.; Campbell,E. M.PLoS ONE 2013 ;8(4):e62143

Spatiotemporal dynamics of adenovirus membrane rupture and endosomal escape.Maier,O.; Marvin,S. A.; Wodrich,H.; Campbell,E. M.; Wiethoff,C. M.Journal of virology 2012 ;86(19):10821-10828

Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome.Barlan,A. U.; Danthi,P.; Wiethoff,C. M.Virology 2011 ;412(2):306-314

Adenovirus membrane penetration activates the NLRP3 inflammasome.Barlan,A. U.; Griffin,T. M.; McGuire,K. A.; Wiethoff,C. M.Journal of virology 2011 ;85(1):146-155

Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species.McGuire,K. A.; Barlan,A. U.; Griffin,T. M.; Wiethoff,C. M.Journal of virology 2011 ;85(20):10806-10813

An N-terminal domain of adenovirus protein VI fragments membranes by inducing positive membrane curvature.Maier,O.; Galan,D. L.; Wodrich,H.; Wiethoff,C. M.Virology 2010 ;402(1):11-19

N-terminal -helix-independent membrane interactions facilitate adenovirus protein VI induction of membrane tubule formation.Maier,O.; Wiethoff,C. M.Virology 2010 ;408(1):31-38

Interests
  • Hockey