I. Caroline LePoole
  • Professor
  • Pathology
  • Microbiology and Immunology

Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralinBonchak,J. G.; Eby,J. M.; Willenborg,K. A.; Chrobak,D.; Henning,S. W.; Krzywiec,A.; Johnson,S. L.; Le Poole,I. C.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2014 ; ( ):

Vitiligo treatment de-mystified: a flow-chart for stratified treatment approaches (commentary)Tung,R.; Le Poole,I. C.Experimental dermatology 2014 ; ( ):

Immune Responses In A Mouse Model Of Vitiligo With Spontaneous Epidermal De- And RepigmentationEby,J. M.; Kang,H. K.; Klarquist,J.; Chatterjee,S.; Mosenson,J. A.; Nishimura,M. I.; Garrett-Mayer,E.; Jack Longley,B.; Engelhard,V. H.; Mehrotra,S.; Le Poole,I. C.Pigment Cell & Melanoma Research 2014 ; ( ):

Mutant HSP70 reverses autoimmune depigmentation in vitiligoMosenson,J. A.; Zloza,A.; Nieland,J. D.; Garrett-Mayer,E.; Eby,J. M.; Huelsmann,E. J.; Kumar,P.; Denman,C. J.; Lacek,A. T.; Kohlhapp,F. J.; Alamiri,A.; Hughes,T.; Bines,S. D.; Kaufman,H. L.; Overbeck,A.; Mehrotra,S.; Hernandez,C.; Nishimura,M. I.; Guevara-Patino,J. A.; Le Poole,I. C.Science translational medicine 2013 ;5(174):174ra28

A central role for inducible heat-shock protein 70 in autoimmune vitiligoMosenson,J. A.; Eby,J. M.; Hernandez,C.; Le Poole,I. C.Experimental dermatology 2013 ; ( ):

Preferential secretion of inducible hsp70 by vitiligo melanocytes under stressMosenson,J. A.; Flood,K.; Klarquist,J.; Eby,J. M.; Koshoffer,A.; Boissy,R. E.; Overbeck,A.; Tung,R. C.; Le Poole,I. C.Pigment Cell & Melanoma Research 2013 ; ( ):

Positioning Ganglioside D3 as an Immunotherapeutic Target in LymphangioleiomyomatosisGilbert,E. R.; Eby,J. M.; Hammer,A. M.; Klarquist,J. S.; Christensen,D. G.; Barfuss,A. J.; Boissy,R. E.; Picken,M. M.; Love,R. B.; Dilling,D. F.; Le Poole,I. C.The American journal of pathology 2013 ; ( ):

Renal angiomyolipoma, fat-poor variant-a clinicopathologic mimicker of malignancyMehta,V.; Venkataraman,G.; Antic,T.; Rubinas,T. C.; Le Poole,I. C.; Picken,M. M.Virchows Archiv : an international journal of pathology 2013 ; ( ):

Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus ConferenceEzzedine,K.; Lim,H. W.; Suzuki,T.; Katayama,I.; Hamzavi,I.; Lan,C. C.; Goh,B. K.; Anbar,T.; Silva de Castro,C.; Lee,A. Y.; Parsad,D.; van Geel,N.; Le Poole,I. C.; Oiso,N.; Benzekri,L.; Spritz,R.; Gauthier,Y.; Hann,S. K.; Picardo,M.; Taieb,A.; Vitiligo Global Issue Consensus Conference PanelistsPigment Cell & Melanoma Research 2012 ;25(3):E1-13

A current viewpoint of lymphangioleiomyomatosis supporting immunotherapeutic treatment optionsDilling,D. F.; Gilbert,E. R.; Picken,M. M.; Eby,J. M.; Love,R. B.; Le Poole,I. C.American Journal of Respiratory Cell & Molecular Biology 2012 ;46(1):1-5

A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in miceMehrotra,S.; Al-Khami,A. A.; Klarquist,J.; Husain,S.; Naga,O.; Eby,J. M.; Murali,A. K.; Lyons,G. E.; Li,M.; Spivey,N. D.; Norell,H.; Martins da Palma,T.; Onicescu,G.; Diaz-Montero,C. M.; Garrett-Mayer,E.; Cole,D. J.; Le Poole,I. C.; Nishimura,M. I.Journal of immunology (Baltimore, Md.: 1950) 2012 ;189(4):1627-1638

Heme oxygenase-1 expression protects melanocytes from stress-induced cell death: implications for vitiligo.Elassiuty,Y. E.; Klarquist,J.; Speiser,J.; Yousef,R. M.; El Refaee,A. A.; Hunter,N. S.; Shaker,O. G.; Gundeti,M.; Nieuweboer-Krobotova,L.; Le Poole,I. C.Experimental dermatology 2011 ;20(6):496-501

Topical application of bleaching phenols; in-vivo studies and mechanism of action relevant to melanoma treatment.Hariharan,V.; Toole,T.; Klarquist,J.; Mosenson,J.; Longley,B. J.; Le Poole,I. C.Melanoma research 2011 ;21(2):115-126

Notch signaling regulates mouse and human Th17 differentiation.Keerthivasan,S.; Suleiman,R.; Lawlor,R.; Roderick,J.; Bates,T.; Minter,L.; Anguita,J.; Juncadella,I.; Nickoloff,B. J.; Le Poole,I. C.; Miele,L.; Osborne,B. A.Journal of Immunology 2011 ;187(2):692-701

Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation.Hariharan,V.; Klarquist,J.; Reust,M. J.; Koshoffer,A.; McKee,M. D.; Boissy,R. E.; Le Poole,I. C.Journal of Investigative Dermatology 2010 ;130(1):211-220

Reduced skin homing by functional Treg in vitiligoKlarquist,J.; Denman,C. J.; Hernandez,C.; Wainwright,D. A.; Strickland,F. M.; Overbeck,A.; Mehrotra,S.; Nishimura,M. I.; Le Poole,I. C.Pigment Cell & Melanoma Research 2010 ;23(2):276-286

Functional alterations in protein kinase C beta II expression in melanoma.Voris,J. P.; Sitailo,L. A.; Rahn,H. R.; Defnet,A.; Gerds,A. T.; Sprague,R.; Yadav,V.; Le Poole,I. C.; Denning,M. F.Pigment Cell & Melanoma Research 2010 ;23(2):216-224

Relationship between CD8-dependent antigen recognition, T cell functional avidity, and tumor cell recognitionMoore,T. V.; Lyons,G. E.; Brasic,N.; Roszkowski,J. J.; Voelkl,S.; Mackensen,A.; Kast,W. M.; Le Poole,I. C.; Nishimura,M. I.Cancer immunology, immunotherapy : CII 2009 ;58(5):719-728

De-N-acetyl GM3 promotes melanoma cell migration and invasion through urokinase plasminogen activator receptor signaling-dependent MMP-2 activationLiu,J. W.; Sun,P.; Yan,Q.; Paller,A. S.; Gerami,P.; Ho,N.; Vashi,N.; Le Poole,I. C.; Wang,X. Q.Cancer research 2009 ;69(22):8662-8669

Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells.Klarquist,J.; Barfuss,A.; Kandala,S.; Reust,M. J.; Braun,R. K.; Hu,J.; Dilling,D. F.; McKee,M. D.; Boissy,R. E.; Love,R. B.; Nishimura,M. I.; Le Poole,I. C.American Journal of Pathology 2009 ;175(6):2463-2472

Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?Schallreuter,K. U.; Bahadoran,P.; Picardo,M.; Slominski,A.; Elassiuty,Y. E.; Kemp,E. H.; Giachino,C.; Liu,J. B.; Luiten,R. M.; Lambe,T.; Le Poole,I. C.; Dammak,I.; Onay,H.; Zmijewski,M. A.; Dell'Anna,M. L.; Zeegers,M. P.; Cornall,R. J.; Paus,R.; Ortonne,J. P.; Westerhof,W.Experimental dermatology 2008 ;17(2):139-40; discussion 141-60

HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.Denman,C. J.; McCracken,J.; Hariharan,V.; Klarquist,J.; Oyarbide-Valencia,K.; Guevara-Patino,J. A.; Le Poole,I. C.Journal of Investigative Dermatology 2008 ;128(8):2041-2048

Immortalization of human melanocytes does not alter the de novo properties of nitric oxide to induce cell detachment from extracellular matrix components via cGMPIvanova,K.; Lambers,B.; van den Wijngaard,R.; Le Poole,I. C.; Grigorieva,O.; Gerzer,R.; Das,P. K.In vitro cellular & developmental biology.Animal 2008 ;44(8-9):385-395

Langerhans cells and dendritic cells are cytotoxic towards HPV16 E6 and E7 expressing target cells.Le Poole,I. C.; ElMasri,W. M.; Denman,C. J.; Kroll,T. M.; Bommiasamy,H.; Lyons Eiben,G.; Kast,W. M.Cancer Immunology, Immunotherapy 2008 ;57(6):789-797

Autoimmune etiology of generalized vitiligoLe Poole,I. C.; Luiten,R. M.Current directions in autoimmunity 2008 ;10( ):227-243

T-cell avidity and tuning: the flexible connection between tolerance and autoimmunityvan den Boorn,J. G.; Le Poole,I. C.; Luiten,R. M.International reviews of immunology 2006 ;25(3-4):235-258

Therapeutic implications of autoimmune vitiligo T cellsOyarbide-Valencia,K.; van den Boorn,J. G.; Denman,C. J.; Li,M.; Carlson,J. M.; Hernandez,C.; Nishimura,M. I.; Das,P. K.; Luiten,R. M.; Le Poole,I. C.Autoimmunity Reviews 2006 ;5(7):486-492

4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo.Kroll,T. M.; Bommiasamy,H.; Boissy,R. E.; Hernandez,C.; Nickoloff,B. J.; Mestril,R.; Le Poole,I. C.Journal of Investigative Dermatology 2005 ;124(4):798-806

Autoimmune aspects of depigmentation in vitiligoLe Poole,I. C.; Wankowicz-Kalinska,A.; van den Wijngaard,R. M.; Nickoloff,B. J.; Das,P. K.Journal of Investigative Dermatology.Symposium Proceedings 2004 ;9(1):68-72

Expression of gp100 and CDK2 in melanoma cells is not co-regulated by a shared promoter region.Stennett,L. S.; Riker,A. I.; Kroll,T. M.; Chamberlin,J.; Miki,T.; Nickoloff,B. J.; Le Poole,I. C.Pigment Cell Research 2004 ;17(5):525-532

Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genesCassetti,M. C.; McElhiney,S. P.; Shahabi,V.; Pullen,J. K.; Le Poole,I. C.; Eiben,G. L.; Smith,L. R.; Kast,W. M.Vaccine 2004 ;22(3-4):520-527

Cervical cancer vaccines: recent advances in HPV researchEiben,G. L.; da Silva,D. M.; Fausch,S. C.; Le Poole,I. C.; Nishimura,M. I.; Kast,W. M.Viral immunology 2003 ;16(2):111-121

HPV protein/peptide vaccines: from animal models to clinical trialsFausch,S. C.; Da Silva,D. M.; Eiben,G. L.; Le Poole,I. C.; Kast,W. M.Frontiers in bioscience : a journal and virtual library 2003 ;8( ):s81-91

Advances in prophylactic cancer vaccine researchLe Poole,I. C.; Bommiasamy,H.; Bocchetta,M.; Kast,W. M.Expert Review of Anticancer Therapy 2003 ;3(4):537-545

Recent progress in tumour vaccine developmentLe Poole,I. C.; Bommiasamy,H.; Kast,W. M.Expert opinion on investigational drugs 2003 ;12(6):971-981

Expansion of vitiligo lesions is associated with reduced epidermal CDw60 expression and increased expression of HLA-DR in perilesional skin.Le Poole,I. C.; Stennett,L. S.; Bonish,B. K.; Dee,L.; Robinson,J. K.; Hernandez,C.; Hann,S. K.; Nickoloff,B. J.British Journal of Dermatology 2003 ;149(4):739-748

Emerging strategies in tumor vaccinesLe Poole,I. C.; Gerberi,M. A.; Kast,W. M.Current opinion in oncology 2002 ;14(6):641-648

Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cellsLe Poole,I. C.; Riker,A. I.; Quevedo,M. E.; Stennett,L. S.; Wang,E.; Marincola,F. M.; Kast,W. M.; Robinson,J. K.; Nickoloff,B. J.The American journal of pathology 2002 ;160(2):521-528

A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligoDas,P. K.; van den Wijngaard,R. M.; Wankowicz-Kalinska,A.; Le Poole,I. C.Trends in immunology 2001 ;22(3):130-136

Inhibition of melanosome transfer from melanocytes to keratinocytes by lectins and neoglycoproteins in an in vitro model systemMinwalla,L.; Zhao,Y.; Cornelius,J.; Babcock,G. F.; Wickett,R. R.; Le Poole,I. C.; Boissy,R. E.Pigment Cell Research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2001 ;14(3):185-194

Keratinocytes play a role in regulating distribution patterns of recipient melanosomes in vitroMinwalla,L.; Zhao,Y.; Le Poole,I. C.; Wickett,R. R.; Boissy,R. E.The Journal of investigative dermatology 2001 ;117(2):341-347

'VIT1', a novel gene associated with vitiligoLe Poole,I. C.; Sarangarajan,R.; Zhao,Y.; Stennett,L. S.; Brown,T. L.; Sheth,P.; Miki,T.; Boissy,R. E.Pigment Cell Research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2001 ;14(6):475-484

The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activityYang,F.; Sarangarajan,R.; Le Poole,I. C.; Medrano,E. E.; Boissy,R. E.The Journal of investigative dermatology 2000 ;114(1):157-164

PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulumLe Poole,I. C.; Boissy,R. E.; Sarangarajan,R.; Chen,J.; Forristal,J. J.; Sheth,P.; Westerhof,W.; Babcock,G.; Das,P. K.; Saelinger,C. B.In vitro cellular & developmental biology.Animal 2000 ;36(5):309-319

Micro-anatomy related antigen expression in melanocytic lesionsMeije,C. B.; Mooi,W. J.; Le Poole,I. C.; Van Muijen,G. N.; Das,P. K.The Journal of pathology 2000 ;190(5):572-578

Expression and modulation of apoptosis regulatory molecules in human melanocytes: significance in vitiligovan den Wijngaard,R. M.; Aten,J.; Scheepmaker,A.; Le Poole,I. C.; Tigges,A. J.; Westerhof,W.; Das,P. K.The British journal of dermatology 2000 ;143(3):573-581