Karen Griffin
M.D., FACP
Professor
Fellowship Program Director, Nephrology
Nephrology
CONTACT INFORMATION
Specialties
Chronic Kidney Disease, High Blood Pressure, Kidney Transplant, Systemic Lupus Erythematosus, Polycystic Kidney Disease, Kidney Stones, Diabetic Kidney Disease
Board Certifications
Internal Medicine - General Cert: AM Board of Internal Medicine
Nephrology - Subspecialty Cert: AM Board of Internal Medicine
Publications
Large BP-dependent and -independent differences in susceptibility to nephropathy after nitric oxide inhibition in Sprague-Dawley rats from two major suppliers.Griffin,K.; Polichnowski,A.; Licea-Vargas,H.; Picken,M.; Long,J.; Williamson,G.; Bidani,A.American Journal of Physiology - Renal Physiology 2012 ;302(1):F173-82
Large Bp-Dependent and -Independent Differences in Susceptibility to Nephropathy After Nitric Oxide Inhibition in Sprague-Dawley Rats from Two Major SuppliersGriffin,K. A.; Polichnowski,A. J.; Licea-Vargas,H.; Picken,M.; Long,J.; Williamson,G. A.; Bidani,A. K.American journal of physiology.Renal physiology 2011 ; ( ):
Solute and water excretion patterns in patients with nocturnal polyuriaHerek,J. I.; FitzGerald,M. P.; Mohindra,M.; Wickman,C.; Leehey,D. J.; Bidani,A. K.; Griffin,K. A.International Journal of Nephrology & Urology 2010 ;2(4):526-531
Angiotensin II type 2 receptor in chronic kidney disease: the good side of angiotensin II?.Griffin,K. A.; Bidani,A. K.KIDNEY INTERNATIONAL 2009 ;75(10):1006-1008
Protective importance of the myogenic response in the renal circulationBidani,A. K.; Griffin,K. A.; Williamson,G.; Wang,X.; Loutzenhiser,R.HYPERTENSION 2009 ;54(2):393-398
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.Pravenec,M.; Churchill,P. C.; Churchill,M. C.; Viklicky,O.; Kazdova,L.; Aitman,T. J.; Petretto,E.; Hubner,N.; Wallace,C. A.; Zimdahl,H.; Zidek,V.; Landa,V.; Dunbar,J.; Bidani,A. K.; Griffin,K.; Qi,N.; Maxova,M.; Kren,V.; Mlejnek,P.; Wang,J.; Kurtz,T. W.NATURE GENETICS 2008 ;40(8):952-954
Potential Risks of Calcium Channel Blockers in Chronic Kidney Disease.Griffin,K. A.; Bidani,A. K.Current Cardiology Reports 2008 ;10( ):448-455
Adverse renal consequences of obesityGriffin,K. A.; Kramer,H.; Bidani,A. K.American Journal of Physiology - Renal Physiology 2008 ;294(4):F685-96
Systolic and mean blood pressures and afferent arteriolar myogenic response dynamics: a modeling approach.Williamson,G. A.; Loutzenhiser,R.; Wang,X.; Griffin,K. A.; Bidani,A. K.American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2008 ;295(5):R1502-R1511
Dynamic blood pressure load and nephropathy in the ZSF1 (fa/fa cp) model of type 2 diabetes.Griffin,K. A.; Abu-Naser,M.; Abu-Amarah,I.; Picken,M. M.; Williamson,G. A.; Bidani,A. K.American Journal of Physiology - Renal Physiology 2007 ;293(5):F1605-13
Spontaneously reduced blood pressure load in the rat streptozotocin-induced diabetes model: potential pathogenetic relevance.Bidani,A. K.; Picken,M. M.; Hacioglu,R.; Williamson,G.; Griffin,K. A.American Journal of Physiology - Renal Physiology 2007 ;292(2):F647-54
The benefits of renin-angiotensin blockade in hypertension are dependent on blood-pressure lowering.Bidani,A. K.; Griffin,K. A.NATURE CLINICAL PRACTICE NEPHROLOGY 2006 ;2(10):542-543
Repair/regression of renal damage after antihypertensive therapy in the stroke prone SHR (SHRsp) model of malignant nephroscerosisBidani,A. K.; Litbarg,N.; Picken,M. M.; Griffin,K.JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2006 ;17( ):TH-F-DS782
Quantative relationships between blood pressure and renal damage after NO synthase (NOS) inhibition vs. salt supplemental in a renal mass reduction modelGriffin,K. A.; Picken,M. M.; Litbarg,N.; Naser,M.; Williamson,G.; Bidani,A. K.Journal of the American Society of Nephrology: JASN 2006 ;17( ):#F-PO786
Progression of renal disease: renoprotective specificity of renin-angiotensin system blockadeGriffin,K. A.; Bidani,A. K.Clinical Journal of The American Society of Nephrology: CJASN 2006 ;1(5):1054-1065
Characterization of dynamics in renal autoregulation using volterra models.Hacioglu,R.; Williamson,G. A.; Abu-Amarah,I.; Griffin,K. A.; Bidani,A. K.IEEE Transactions on Biomedical Engineering 2006 ;53(11):2166-2176
Altered K channel function in afferent arterioles isolated from remnant kidneysLoutzenhiser,K.; Breaks,J.; Wang,X.; Griffin,K.; Bidani,A. K.Journal of the American Society of Nephrology: JASN 2006 ;17( ):SA-PO675
Renal autoregulation: new perspectives regarding the protective and regulatory roles of the underlying mechanismsLoutzenhiser,R.; Griffin,K.; Williamson,G.; Bidani,A. K.American Journal of Physiology - Regulatory Integrative & Comparative Physiology 2006 ;290(5):R1153-67
Systolic blood pressure as the trigger for the renal myogenic response: protective or autoregulatory?Loutzenhiser,R.; Griffin,K. A.; Bidani,A. K.Current Opinion in Nephrology & Hypertension 2006 ;15(1):41-49
Differences between dilatory and constrictor myogenic responses influence the pressure triggerWilliamson,G.; Loutzenhiser,R.; Wang,X.; Griffin,K.; Bidani,A. K.JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2006 ;17( ):SA-P0678
Hypertension and kidney damage.Griffin,K. A.JOURNAL OF CLINICAL HYPERTENSION 2006 ;8(3):209-214
Recommendations for blood pressure measurement in animals: summary of an AHA scientific statement from the Council on High Blood Pressure Research, Professional and Public Education SubcommitteeKurtz,T. W.; Griffin,K. A.; Bidani,A. K.; Davisson,R. L.; Hall,J. E.Arteriosclerosis, Thrombosis & Vascular Biology 2005 ;25(3):478-479
Recommendations for blood pressure measurement in humans and experimental animals. Part 2: Blood pressure measurement in experimental animals: a statement for professionals from the subcommittee of professional and public education of the American Heart Association council on high blood pressure researchKurtz,T. W.; Griffin,K. A.; Bidani,A. K.; Davisson,R. L.; Hall,J. E.HYPERTENSION 2005 ;45(2):299-310
Differential effects of salt on renal hemodynamics and potential pressure transmission in stroke-prone and stroke-resistant spontaneously hypertensive rats.Abu-Amarah,I.; Bidani,A. K.; Hacioglu,R.; Williamson,G. A.; Griffin,K. A.American Journal of Physiology - Renal Physiology 2005 ;289(2):F305-13
Pathophysiology of hypertensive renal damage: implications for therapyBidani,A. K.; Griffin,K. A.HYPERTENSION 2004 ;44(5):595-601
Hypertensive renal damage: insights from animal models and clinical relevanceGriffin,K. A.; Bidani,A. K.CURRENT HYPERTENSION REPORTS 2004 ;6(2):145-153
Effects of calcium channel blockers on "dynamic" and "steady-state step" renal autoregulation.Griffin,K. A.; Hacioglu,R.; Abu-Amarah,I.; Loutzenhiser,R.; Williamson,G. A.; Bidani,A. K.American Journal of Physiology - Renal Physiology 2004 ;286(6):F1136-43
Blood pressure lability and glomerulosclerosis after normotensive 5/6 renal mass reduction in the rat.Griffin,K. A.; Picken,M. M.; Bidani,A. K.KIDNEY INTERNATIONAL 2004 ;65(1):209-218
Long-term blood-pressure monitoring in unrestrained animals.Griffin,K. A.; Abu-Amarah,I.; Bidani,A. K.Methods in Molecular Medicine 2003 ;86( ):329-340
Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependentGriffin,K. A.; Abu-Amarah,I.; Picken,M. M.; Bidani,A. K.HYPERTENSION 2003 ;41(2):201-206
Low protein diet mediated renoprotection in remnant kidneys: Renal autoregulatory versus hypertrophic mechanisms.Griffin,K. A.; Picken,M. M.; Giobbie-Hurder,A.; Bidani,A. K.KIDNEY INTERNATIONAL 2003 ;63(2):607-616
"Step" vs. "dynamic" autoregulation: implications for susceptibility to hypertensive injury.Bidani,A. K.; Hacioglu,R.; Abu-Amarah,I.; Williamson,G. A.; Loutzenhiser,R.; Griffin,K. A.American Journal of Physiology - Renal Physiology 2003 ;285(1):F113-20
Long-term renal consequences of hypertension for normal and diseased kidneysBidani,A. K.; Griffin,K. A.Current Opinion in Nephrology & Hypertension 2002 ;11(1):73-80
Increased genetic susceptibility to renal damage in the stroke-prone spontaneously hypertensive rat.Churchill,P. C.; Churchill,M. C.; Griffin,K. A.; Picken,M. M.; Webb,R. C.; Kurtz,T. W.; Bidani,A. K.KIDNEY INTERNATIONAL 2002 ;61(5):1794-1800
Relative antihypertensive and glomeruloprotective efficacies of enalapril and candesartan cilexetil in the remnant kidney model.Griffin,K. A.; Picken,M. M.; Bakris,G.; Bidani,A. K.Journal of Renin-Angiotensin-Aldosterone System 2001 ;2(1):s191-s195
Comparative effects of selective T- and L-type calcium channel blockers in the remnant kidney model.Griffin,K. A.; Picken,M. M.; Bakris,G. L.; Bidani,A. K.HYPERTENSION 2001 ;37(5):1268-1272
Differential salt-sensitivity in the pathogenesis of renal damage in SHR and stroke prone SHR.Griffin,K. A.; Churchill,P. C.; Picken,M. M.; Webb,R. C.; Kurtz,T. W.; Bidani,A. K.AMERICAN JOURNAL OF HYPERTENSION 2001 ;14(4 Pt 1):311-320
Genetic susceptibility to renal injury in hypertensionBidani,A. K.; Griffin,K. A.; Churchill,P. C.; Churchill,M. C.; St Lezin,E.; Kurtz,T. W.Experimental nephrology 2001 ;9(6):360-365
Lack of evidence of blood pressure-independent protection by renin-angiotensin system blockade after renal ablationBidani,A. K.; Griffin,K. A.; Bakris,G.; Picken,M. M.KIDNEY INTERNATIONAL 2000 ;57(4):1651-1661
Functional and structural correlates of glomerulosclerosis after renal mass reduction in the rat.Griffin,K. A.; Picken,M. M.; Churchill,M.; Churchill,P.; Bidani,A. K.JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2000 ;11(3):497-506
Genetic isolation of a chromosome 1 region affecting susceptibility to hypertension-induced renal damage in the spontaneously hypertensive rat.St Lezin,E.; Griffin,K. A.; Picken,M. M.; Churchill,M. C.; Churchill,P. C.; Kurtz,T. W.; Liu,W.; Wang,N.; Kren,V.; Zidek,V.; Pravenec,M.; Bidani,A. K.HYPERTENSION 1999 ;34(2):187-191
Renal injury and salt-sensitive hypertension after exposure to catecholamines.Johnson,R. J.; Gordon,K. L.; Suga,S.; Duijvestijn,A. M.; Griffin,K.; Bidani,A. K.HYPERTENSION 1999 ;34(1):151-159
Class differences in the effects of calcium channel blockers in the rat remnant kidney model.Griffin,K. A.; Picken,M. M.; Bakris,G. L.; Bidani,A. K.KIDNEY INTERNATIONAL 1999 ;55(5):1849-1860
Calcium-channel blockers and the progression of renal disease.Griffin,K. A.; Bidani,A. K.CURRENT HYPERTENSION REPORTS 1999 ;1(5):436-445
Combined effects of an angiotensin converting enzyme inhibitor and a calcium antagonist on renal injury.Bakris,G. L.; Griffin,K. A.; Picken,M. M.; Bidani,A. K.JOURNAL OF HYPERTENSION 1997 ;15(10):1181-1185
Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.Churchill,P. C.; Churchill,M. C.; Bidani,A. K.; Griffin,K. A.; Picken,M. M.; Pravenec,M.; Kren,V.; St Lezin,E.; Wang,J. M.; Wang,N.; Kurtz,T. W.JOURNAL OF CLINICAL INVESTIGATION 1997 ;100(6):1373-1382
Chronic alpha 1-adrenoreceptor stimulation increases DNA synthesis in rat arterial wall. Modulation of responsiveness after vascular injury.deBlois,D.; Schwartz,S. M.; van Kleef,E. M.; Su,J. E.; Griffin,K. A.; Bidani,A. K.; Daemen,M. J.; Lombardi,D. M.Arteriosclerosis, Thrombosis & Vascular Biology 1996 ;16(9):1122-1129
Deleterious effects of calcium channel blockade on pressure transmission and glomerular injury in rat remnant kidneys.Griffin,K. A.; Picken,M. M.; Bidani,A. K.JOURNAL OF CLINICAL INVESTIGATION 1995 ;96(2):793-800
Calcium channel blockers and renal protection: is there an optimal dose?[comment]Bidani,A. K.; Griffin,K. A.Journal of Laboratory & Clinical Medicine 1995 ;125(5):553-555
Renal ablation acutely transforms 'benign' hypertension to 'malignant' nephrosclerosis in hypertensive rats.Bidani,A. K.; Griffin,K. A.; Plott,W.; Schwartz,M. M.HYPERTENSION 1994 ;24(3):309-316
Method of renal mass reduction is a critical modulator of subsequent hypertension and glomerular injury.Griffin,K. A.; Picken,M. M.; Bidani,A. K.JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 1994 ;4(12):2023-2031
Radiotelemetric BP monitoring, antihypertensives and glomeruloprotection in remnant kidney model.Griffin,K. A.; Picken,M. M.; Bidani,A. K.KIDNEY INTERNATIONAL 1994 ;46(4):1010-1018
Role of endothelium-derived nitric oxide in hemodynamic adaptations after graded renal mass reduction.Griffin,K. A.; Bidani,A. K.; Ouyang,J.; Ellis,V.; Churchill,M.; Churchill,P. C.AMERICAN JOURNAL OF PHYSIOLOGY 1993 ;264(6 Pt 2):R1254-9
Genetic predisposition to hypertension and microvascular injury in the remnant kidney model.Bidani,A. K.; Griffin,K. A.; Plott,W.; Schwartz,M. M.Journal of Laboratory & Clinical Medicine 1993 ;122(3):284-291
Continuous telemetric blood pressure monitoring and glomerular injury in the rat remnant kidney model.Bidani,A. K.; Griffin,K. A.; Picken,M. M.; Lansky,D. M.AMERICAN JOURNAL OF PHYSIOLOGY 1993 ;265(3 Pt 2):F391-8
Prostaglandins do not mediate impaired autoregulation or increased renin secretion in remnant rat kidneys.Griffin,K. A.; Bidani,A. K.; Picken,M. M.; Ellis,V. R.; Churchill,P. C.AMERICAN JOURNAL OF PHYSIOLOGY 1992 ;263(6 Pt 2):F1057-62
The technique of percutaneous renal biopsy. How to minimize risk while ensuring adequate tissue sampling.Griffin,K. A.JOURNAL OF CRITICAL ILLNESS 1992 ;7(2):284-292
Disorders of sodium and water balance.Griffin,K. A.; Bidani,A. K.JOURNAL OF CRITICAL ILLNESS 1990 ;5(10):1054-1070
Guidelines for determining the cause of acute renal failure.Griffin,K. A.; Bidani,A. K.JOURNAL OF CRITICAL ILLNESS 1989 ;4(9):32-49
Pulmonary-renal syndrome of bacterial endocarditis mimicking Goodpasture's syndrome.Griffin,K. A.; Schwartz,M. M.; Korbet,S. M.AMERICAN JOURNAL OF KIDNEY DISEASES 1989 ;14(4):329-332
Education
Medical School
Rush Medical College of Rush University
Residency
Rush-Presbyterian-St. Luke's Medical Center, Internal Medicine: General
Fellowship
Rush-Presbyterian-St. Luke's Medical Center, Internal Medicine: Nephrology
Interests & Hobbies
Bicycling
Exercise
Gardening
Fishing