Manuel Diaz
  • Professor
  • Hematology/Oncology
  • Microbiology and Immunology

In relation to the article "Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases" by Bogerhausen et alDiaz,M. O.CLINICAL GENETICS 2013 ;83(3):295

Multiple clonal MLL fusions in a patient receiving CHOP-based chemotherapyShih,S. J.; Fass,J.; Buffalo,V.; Lin,D.; Singh,S. P.; Diaz,M. O.; Vaughan,A. T.British journal of haematology 2012 ;159(1):50-57

Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3.Chauhan,C.; Zraly,C. B.; Parilla,M.; Diaz,M. O.; Dingwall,A. K.Development 2012 ;139(11):1997-2008

The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repressionPark,S.; Osmers,U.; Raman,G.; Schwantes,R. H.; Diaz,M. O.; Bushweller,J. H.Biochemistry 2010 ;49(31):6576-6586

Diffuse centromere and chromosome polymorphism in haplogyne spiders of the families Dysderidae and Segestriidae.Diaz,M. O.; Maynard,R.; Brum-Zorrilla,N.Cytogenetic & Genome Research 2010 ;128(1-3):131-138

11q21.1-11q23.3 Is a site of intrinsic genomic instability triggered by irradiationDu,N.; Baker,P. M.; Do,T. U.; Bien,C.; Bier-Laning,C. M.; Singh,S.; Shih,S. J.; Diaz,M. O.; Vaughan,A. T.Genes, chromosomes & cancer 2010 ;49(9):831-843

Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II bindingLe,H.; Singh,S.; Shih,S. J.; Du,N.; Schnyder,S.; Loredo,G. A.; Bien,C.; Michaelis,L.; Toor,A.; Diaz,M. O.; Vaughan,A. T.Genes, chromosomes & cancer 2009 ;48(9):806-815

c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.Guo,Y.; Niu,C.; Breslin,P.; Tang,M.; Zhang,S.; Wei,W.; Kini,A. R.; Paner,G. P.; Alkan,S.; Morris,S. W.; Diaz,M.; Stiff,P. J.; Zhang,J.Blood 2009 ;114(10):2097-2106

CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencingTie,F.; Banerjee,R.; Stratton,C. A.; Prasad-Sinha,J.; Stepanik,V.; Zlobin,A.; Diaz,M. O.; Scacheri,P. C.; Harte,P. J.Development (Cambridge, England) 2009 ;136(18):3131-3141

Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization.Chen,J.; Santillan,D. A.; Koonce,M.; Wei,W.; Luo,R.; Thirman,M. J.; Zeleznik-Le,N. J.; Diaz,M. O.Cancer research 2008 ;68(15):6199-6207

TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice.Tang,M.; Wei,X.; Guo,Y.; Breslin,P.; Zhang,S.; Zhang,S.; Wei,W.; Xia,Z.; Diaz,M.; Akira,S.; Zhang,J.Journal of Experimental Medicine 2008 ;205(7):1611-1619

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.Erfurth,F. E.; Popovic,R.; Grembecka,J.; Cierpicki,T.; Theisler,C.; Xia,Z. B.; Stuart,T.; Diaz,M. O.; Bushweller,J. H.; Zeleznik-Le,N. J.Proceedings of the National Academy of Sciences of the United States of America 2008 ;105(21):7517-7522

Surviving apoptosis: a possible mechanism of benzene-induced leukemiaVaughan,A. T.; Betti,C. J.; Villalobos,M. J.; Premkumar,K.; Cline,E.; Jiang,Q.; Diaz,M. O.Chemico-biological interactions 2005 ;153-154( ):179-185

The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.Xia,Z. B.; Popovic,R.; Chen,J.; Theisler,C.; Stuart,T.; Santillan,D. A.; Erfurth,F.; Diaz,M. O.; Zeleznik-Le,N. J.Proceedings of the National Academy of Sciences of the United States of America 2005 ;102(39):14028-14033

Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity.Betti,C. J.; Villalobos,M. J.; Jiang,Q.; Cline,E.; Diaz,M. O.; Loredo,G.; Vaughan,A. T.Leukemia 2005 ;19(12):2289-2295

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein.Xia,Z. B.; Anderson,M.; Diaz,M. O.; Zeleznik-Le,N. J.Proceedings of the National Academy of Sciences of the United States of America 2003 ;100(14):8342-8347

Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of divisionBetti,C. J.; Villalobos,M. J.; Diaz,M. O.; Vaughan,A. T.Cancer research 2003 ;63(6):1377-1381

Role for Id-1 in immunobiology of normal keratinocytes and in basal cell carcinoma.Chaturvedi,V.; Bonish,B.; Bacon,P.; Qin,J. Z.; Denning,M. F.; Foreman,K. E.; Diaz,M. O.; Robinson,J.; Nickoloff,B. J.Experimental dermatology 2003 ;12(3):255-260

Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytesChaturvedi,V.; Cesnjaj,M.; Bacon,P.; Panella,J.; Choubey,D.; Diaz,M. O.; Nickoloff,B. J.The American journal of pathology 2003 ;162(1):161-170

A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cellsAnderson,M.; Fair,K.; Amero,S.; Nelson,S.; Harte,P. J.; Diaz,M. O.Development genes and evolution 2002 ;212(3):107-113

Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cellsFair,K.; Anderson,M.; Bulanova,E.; Mi,H.; Tropschug,M.; Diaz,M. O.Molecular and cellular biology 2001 ;21(10):3589-3597

Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair systemBetti,C. J.; Villalobos,M. J.; Diaz,M. O.; Vaughan,A. T.Cancer research 2001 ;61(11):4550-4555

Abnormal NF-kappaB signaling pathway with enhanced susceptibility to apoptosis in immortalized keratinocytesChaturvedi,V.; Qin,J. Z.; Denning,M. F.; Choubey,D.; Diaz,M. O.; Nickoloff,B. J.Journal of dermatological science 2001 ;26(1):67-78

Id-1 delays senescence but does not immortalize keratinocytesNickoloff,B. J.; Chaturvedi,V.; Bacon,P.; Qin,J. Z.; Denning,M. F.; Diaz,M. O.The Journal of biological chemistry 2000 ;275(36):27501-27504

Medical School
  • University of the Republic