Phong Le
  • Professor
  • Microbiology and Immunology
Research Keywords
  • Aging/Gerontology
  • Immune System
  • Immunosuppression
  • Stem Cell

IL22 Regulates Human Urothelial Cell Sensory and Innate Functions through Modulation of the Acetylcholine Response, Immunoregulatory Cytokines and Antimicrobial Peptides: Assessment of an In Vitro ModelLe,P. T.; Pearce,M. M.; Zhang,S.; Campbell,E. M.; Fok,C. S.; Mueller,E. R.; Brincat,C. A.; Wolfe,A. J.; Brubaker,L.PLoS ONE 2014 ;9(10):e111375

A potential role for B cells in suppressed immune responses in cord blood transplant recipientsBeaudette-Zlatanova,B. C.; Le,P. T.; Knight,K. L.; Zhang,S.; Zakrzewski,S.; Parthasarathy,M.; Stiff,P. J.Bone marrow transplantation 2013 ;48(1):85-93

Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow nicheZook,E. C.; Zhang,S.; Gerstein,R. M.; Witte,P. L.; Le,P. T.Journal of immunology (Baltimore, Md.: 1950) 2013 ;191(11):5583-5593

Mixed lineage kinase 3 modulates beta-catenin signaling in cancer cellsThylur,R. P.; Senthivinayagam,S.; Campbell,E. M.; Rangasamy,V.; Thorenoor,N.; Sondarva,G.; Mehrotra,S.; Mishra,P.; Zook,E.; Le,P. T.; Rana,A.; Rana,B.The Journal of biological chemistry 2011 ;286(43):37470-37482

A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells.Beaudette-Zlatanova,B. C.; Knight,K. L.; Zhang,S.; Stiff,P. J.; Zuniga-Pflucker,J. C.; Le,P. T.Experimental hematology 2011 ;39(5):570-579

Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells.Zook,E. C.; Krishack,P. A.; Zhang,S.; Zeleznik-Le,N. J.; Firulli,A. B.; Witte,P. L.; Le,P. T.Blood 2011 ;118(22):5723-5731

In vitro requirement for periostin in B lymphopoiesis.Siewe,B. T.; Kalis,S. L.; Le,P. T.; Witte,P. L.; Choi,S.; Conway,S. J.; Druschitz,L.; Knight,K. L.Blood 2011 ;117(14):3770-3779

Migration of immature and mature B cells in the aged microenvironmentWols,H. A.; Johnson,K. M.; Ippolito,J. A.; Birjandi,S. Z.; Su,Y.; Le,P. T.; Witte,P. L.Immunology 2009 ; ( ):

The effects of microenvironment and internal programming on plasma cell survivalMinges Wols,H. A.; Ippolito,J. A.; Yu,Z.; Palmer,J. L.; White,F. A.; Le,P. T.; Witte,P. L.International immunology 2007 ;19(7):837-846

Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic nicheHofmeister,C. C.; Zhang,J.; Knight,K. L.; Le,P.; Stiff,P. J.Bone marrow transplantation 2007 ;39(1):11-23

The effects of ethanol and the serotonin(1A) agonist ipsapirone on the expression of the serotonin(1A) receptor and several antiapoptotic proteins in fetal rhombencephalic neurons.Druse,M. J.; Tajuddin,N. F.; Gillespie,R. A.; Le,P.Brain research 2006 ;1092(1):79-86

Signaling pathways involved with serotonin1A agonist-mediated neuroprotection against ethanol-induced apoptosis of fetal rhombencephalic neurons.Druse,M.; Tajuddin,N. F.; Gillespie,R. A.; Le,P.Brain Research.Developmental Brain Research 2005 ;159(1):18-28

The serotonin-1A agonist ipsapirone prevents ethanol-associated death of total rhombencephalic neurons and prevents the reduction of fetal serotonin neurons.Druse,M. J.; Tajuddin,N. F.; Gillespie,R. A.; Dickson,E.; Atieh,M.; Pietrzak,C. A.; Le,P. T.Brain Research.Developmental Brain Research 2004 ;150(2):79-88

T cell generation including positive and negative selection ex vivo in a three-dimensional matrixMarshall,D.; Bagley,J.; Le,P.; Hogquist,K.; Cyr,S.; Von Schild,E.; Pykett,M.; Rosenzweig,M.Journal of hematotherapy & stem cell research 2003 ;12(5):565-574

Role of stromal cells and their products in protecting young and aged B-lineage precursors from dexamethasone-induced apoptosis.Pifer,J.; Stephan,R. P.; Lill-Elghanian,D. A.; Le,P. T.; Witte,P. L.Mechanisms of Ageing & Development 2003 ;124(2):207-218

Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartmentsOrtman,C. L.; Dittmar,K. A.; Witte,P. L.; Le,P. T.International immunology 2002 ;14(7):813-822

T cell receptor excision circle assessment of thymopoiesis in aging miceSempowski,G. D.; Gooding,M. E.; Liao,H. X.; Le,P. T.; Haynes,B. F.Molecular immunology 2002 ;38(11):841-848

Alterations in CD30(+) T cells in monoclonal gammopathy of undetermined significance.Ellis,T. M.; Le,P. T.; DeVries,G.; Stubbs,E.; Fisher,M.; Bhoopalam,N.Clinical Immunology 2001 ;98(3):301-307

Alterations in peripheral B cells and B cell progenitors following androgen ablation in mice.Ellis,T. M.; Moser,M. T.; Le,P. T.; Flanigan,R. C.; Kwon,E. D.International immunology 2001 ;13(4):553-558

Apoptosis: one of the mechanisms that maintains unresponsiveness of the intestinal mucosal immune systemBu,P.; Keshavarzian,A.; Stone,D. D.; Liu,J.; Le,P. T.; Fisher,S.; Qiao,L.Journal of immunology (Baltimore, Md.: 1950) 2001 ;166(10):6399-6403

TGF-beta1 and IL-6 expression in rat pineal gland is regulated by norepinephrine and interleukin-1beta.Tsai,S. Y.; Schluns,K. S.; Le,P. T.; McNulty,J. A.Histology & Histopathology 2001 ;16(4):1135-1141

Human thymic epithelial cells inhibit IL-15- and IL-2-driven differentiation of NK cells from the early human thymic progenitorsLe,P. T.; Adams,K. L.; Zaya,N.; Mathews,H. L.; Storkus,W. J.; Ellis,T. M.Journal of immunology (Baltimore, Md.: 1950) 2001 ;166(4):2194-2201

  • Duke University Medical Center, Non-GME Medical Training
  • Mandarin- Cantonese- Vietnamese
  • Woodworking
  • Fly Fishing