Renzhi Han
  • Assistant Professor
  • Cell and Molecular Physiology
Research Keywords
  • Bioengineering
  • Biotechnology
  • Cardiovascular System
  • Gene Therapy
  • Muscle Disorders
  • Muscular Dystrophy
  • Stem Cell

Anoctamin 6 Regulates C2C12 Myoblast ProliferationZhao,P.; Torcaso,A.; Mariano,A.; Xu,L.; Mohsin,S.; Zhao,L.; Han,R.PLoS ONE 2014 ;9(3):e92749

Dysferlin-deficient muscular dystrophy and innate immune activationMariano,A.; Henning,A.; Han,R.The FEBS journal 2013 ;280(17):4165-4176

Cardiac Myosin binding protein-C plays no regulatory role in skeletal muscle structure and functionLin,B.; Govindan,S.; Lee,K.; Zhao,P.; Han,R.; Runte,K. E.; Craig,R.; Palmer,B. M.; Sadayappan,S.PLoS ONE 2013 ;8(7):e69671

Targeted Myostatin Gene Editing in Multiple Mammalian Species Directed by a Single Pair of TALE NucleasesXu,L.; Zhao,P.; Mariano,A.; Han,R.Molecular therapy.Nucleic acids 2013 ;2( ):e112

New emerging recombinant HIV-1 strains and close transmission linkage of HIV-1 strains in the Chinese MSM population indicate a new epidemic riskWu,J.; Meng,Z.; Xu,J.; Lei,Y.; Jin,L.; Zhong,P.; Han,R.; Su,B.PLoS ONE 2013 ;8(1):e54322

TRPM2 links oxidative stress to NLRP3 inflammasome activationZhong,Z.; Zhai,Y.; Liang,S.; Mori,Y.; Han,R.; Sutterwala,F. S.; Qiao,L.Nature communications 2013 ;4( ):1611

Dysferlin forms a dimer mediated by the C2 domains and the transmembrane domain in vitro and in living cellsXu,L.; Pallikkuth,S.; Hou,Z.; Mignery,G. A.; Robia,S. L.; Han,R.PLoS ONE 2011 ;6(11):e27884

Equal force recovery in dysferlin-deficient and wild-type muscles following saponin exposure.Zhao,P.; Xu,L.; Ait-Mou,Y.; de Tombe,P. P.; Han,R.Journal of Biomedicine & Biotechnology 2011 ;2011( ):235216

Muscle membrane repair and inflammatory attack in dysferlinopathyHan,R.Skeletal muscle 2011 ;1(1):10

Improving genotyping of the dysferlin null mouse.Han,R.; Kobuke,K.; Anderson,M.; Beltran-Valero de Bernabe,D.; Kobayashi,Y.; Yang,B.; Campbell,K. P.Protocol Exchange 2011 ; ( ):08312012

Dystrophin deficiency exacerbates skeletal muscle pathology in dysferlin-null miceHan,R.; Rader,E. P.; Levy,J. R.; Bansal,D.; Campbell,K. P.Skeletal muscle 2011 ;1(1):35

Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient miceHan,R.; Frett,E. M.; Levy,J. R.; Rader,E. P.; Lueck,J. D.; Bansal,D.; Moore,S. A.; Ng,R.; Beltran-Valero de Bernabe,D.; Faulkner,J. A.; Campbell,K. P.The Journal of clinical investigation 2010 ;120(12):4366-4374

Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycanHan,R.; Kanagawa,M.; Yoshida-Moriguchi,T.; Rader,E. P.; Ng,R. A.; Michele,D. E.; Muirhead,D. E.; Kunz,S.; Moore,S. A.; Iannaccone,S. T.; Miyake,K.; McNeil,P. L.; Mayer,U.; Oldstone,M. B.; Faulkner,J. A.; Campbell,K. P.Proceedings of the National Academy of Sciences of the United States of America 2009 ;106(31):12573-12579

Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injuryHan,R.; Bansal,D.; Miyake,K.; Muniz,V. P.; Weiss,R. M.; McNeil,P. L.; Campbell,K. P.The Journal of clinical investigation 2007 ;117(7):1805-1813

Dysferlin and muscle membrane repairHan,R.; Campbell,K. P.Current opinion in cell biology 2007 ;19(4):409-416

The effect of the PKC inhibitor calphostin C and the PKC agonist phorbol 12-myristate 13-acetate on regulation of cytosolic Ca(2+) in mammalian skeletal muscle cellsHan,R.; Bakker,A. J.Toxicology and applied pharmacology 2006 ;212(3):247-255

Measurement of sub-membrane [Ca2+] in adult myofibers and cytosolic [Ca2+] in myotubes from normal and mdx mice using the Ca2+ indicator FFP-18Han,R.; Grounds,M. D.; Bakker,A. J.Cell calcium 2006 ;40(3):299-307

Fibrin sealant promotes migration and proliferation of human articular chondrocytes: possible involvement of thrombin and protease-activated receptorsKirilak,Y.; Pavlos,N. J.; Willers,C. R.; Han,R.; Feng,H.; Xu,J.; Asokananthan,N.; Stewart,G. A.; Henry,P.; Wood,D.; Zheng,M. H.International journal of molecular medicine 2006 ;17(4):551-558

Thapsigargin modulates osteoclastogenesis through the regulation of RANKL-induced signaling pathways and reactive oxygen species productionYip,K. H.; Zheng,M. H.; Steer,J. H.; Giardina,T. M.; Han,R.; Lo,S. Z.; Bakker,A. J.; Cassady,A. I.; Joyce,D. A.; Xu,J.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005 ;20(8):1462-1471

Evidence of reciprocal regulation between the high extracellular calcium and RANKL signal transduction pathways in RAW cell derived osteoclastsXu,J.; Wang,C.; Han,R.; Pavlos,N.; Phan,T.; Steer,J. H.; Bakker,A. J.; Joyce,D. A.; Zheng,M. H.Journal of cellular physiology 2005 ;202(2):554-562

The effect of chelerythrine on depolarization-induced force responses in skinned fast skeletal muscle fibres of the ratHan,R.; Bakker,A. J.British journal of pharmacology 2003 ;138(3):417-426

Effect of indomethacin on force responses and sarcoplasmic reticulum function in skinned skeletal muscle fibers and cytosolic [Ca2+] in myotubesHan,R.; Suizu,T.; Grounds,M. D.; Bakker,A. J.American journal of physiology.Cell physiology 2003 ;285(4):C881-90


Primary fields of interest:
The research projects in the Han Lab are aimed at elucidating the molecular mechanisms of genetic diseases affecting skeletal and cardiac muscles such as muscular dystrophy and cardiomyopathy. By understanding the molecular mechanisms of these genetic disorders, we hope to have a better understanding of the basic cell biology and shed light on the design of novel therapeutic strategies for treating these devastating diseases.

  • Mandarin Chinese
  • Ping Pong
  • Travel
  • Family Time