Richard Kennedy
  • Professor
  • Cell and Molecular Physiology
  • Molecular Pharmacology and Therapeutics
Research Keywords
  • Alcohol/Alcoholism
  • Burns
  • Cardiopulmonary/Chest Medicine
  • Cardiovascular System
  • Cytokines
  • Estrogen
  • Peptides
  • Receptors
  • Signal Transduction
  • Excitation-Contraction coupling
  • Heart
  • Hormones
  • Infectious Diseases/Agents
  • Inflammation
  • Metabolism

Activities of Nonlysosomal Proteolytic Systems in Skeletal and Cardiac Muscle During Burn-Induced HypermetabolismWong,Y. M.; La Porte,H. M.; Szilagyi,A.; Bach,H. H.,4th; Ke-He,L.; Kennedy,R. H.; Gamelli,R. L.; Shankar,R.; Majetschak,M.Journal of burn care & research : official publication of the American Burn Association 2014 ; ( ):

CAPriCORN: Chicago Area Patient-Centered Outcomes Research NetworkKho,A. N.; Hynes,D. M.; Goel,S.; Solomonides,A. E.; Price,R.; Hota,B.; Sims,S. A.; Bahroos,N.; Angulo,F.; Trick,W. E.; Tarlov,E.; Rachman,F. D.; Hamilton,A.; Kaleba,E. O.; Badlani,S.; Volchenboum,S. L.; Silverstein,J. C.; Tobin,J. N.; Schwartz,M. A.; Levine,D.; Wong,J. B.; Kennedy,R. H.; Krishnan,J. A.; Meltzer,D. O.; Collins,J. M.; Mazany,T.; for the CAPriCORN TeamJournal of the American Medical Informatics Association : JAMIA 2014 ; ( ):

Cardiac dysfunction subsequent to chronic ozone exposure in ratsPerepu,R. S.; Dostal,D. E.; Garcia,C.; Kennedy,R. H.; Sethi,R.MOLECULAR AND CELLULAR BIOCHEMISTRY 2012 ;360(1-2):339-345

The novel antibacterial drug XF-70 is a potent inhibitor of Staphylococcus aureus infection of the burn wound.Hurtuk,M. G.; He,L. K.; Szilagyi,A.; Gamelli,R. L.; Hecht,D. W.; Kennedy,R. H.; Rhys-Williams,W.; Love,W. G.; Shankar,R.Journal of Burn Care & Research 2010 ;31(3):462-469

Effect of anti-oxidant treatment on hyperhomocysteinemia-induced myocardial fibrosis and diastolic dysfunctionJoseph,J.; Joseph,L.; Devi,S.; Kennedy,R. H.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008 ;27(11):1237-1241

Influence of endothelin 1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiationBoerma,M.; Wang,J.; Kulkarni,A.; Roberto,K. A.; Qiu,X.; Kennedy,R. H.; Hauer-Jensen,M.Radiation research 2008 ;170(3):275-283

Cardiovascular effects of hyperhomocysteinemia in conscious unrestrained rats.Kennedy,R. H.; Melchert,R. B.; Joseph,J.American Journal of Hypertension 2006 ;19(1):94-97

Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blocker.Kennedy,R. H.; Owings,R.; Joseph,J.; Melchert,R. B.; Hauer-Jensen,M.; Boerma,M.Clinical & Experimental Pharmacology & Physiology 2006 ;33(4):340-344

TNF-alpha-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes.Zhu,J.; Liu,M.; Kennedy,R. H.; Liu,S. J.Cytokine 2006 ;34(1-2):96-105

Effect of long-term hyperhomocysteinemia on myocardial structure and function in hypertensive rats.Devi,S.; Kennedy,R. H.; Joseph,L.; Shekhawat,N. S.; Melchert,R. B.; Joseph,J.Cardiovascular Pathology 2006 ;15(2):75-82

Influence of mast cells on structural and functional manifestations of radiation-induced heart disease.Boerma,M.; Wang,J.; Wondergem,J.; Joseph,J.; Qiu,X.; Kennedy,R. H.; Hauer-Jensen,M.Cancer research 2005 ;65(8):3100-3107

Deoxycholyltaurine-induced vasodilation of rodent aorta is nitric oxide- and muscarinic M(3) receptor-dependent.Khurana,S.; Yamada,M.; Wess,J.; Kennedy,R. H.; Raufman,J. P.European journal of pharmacology 2005 ;517(1-2):103-110

Gender differences in blood pressure and heart rate in spontaneously hypertensive and Wistar-Kyoto rats.Maris,M. E.; Melchert,R. B.; Joseph,J.; Kennedy,R. H.Clinical & Experimental Pharmacology & Physiology 2005 ;32(1-2):35-39

Contribution of de novo point mutations to the overall mutational burden in mitochondrial DNA of adult rats.Khaidakov,M.; Chavannes-Turesky,N.; Cooney,C. A.; Dupont-Versteegden,E. E.; Kennedy,R. H.; Siegel,E. R.; Khaidakova,G.; Shmookler Reis,R. J.Experimental gerontology 2005 ;40(5):396-402

Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes.Yu,X. W.; Chen,Q.; Kennedy,R. H.; Liu,S. J.Journal of Physiology 2005 ;566(Pt 2):327-340

Both cGMP and peroxynitrite mediate chronic interleukin-6-induced negative inotropy in adult rat ventricular myocytes.Yu,X. W.; Liu,M. Y.; Kennedy,R. H.; Liu,S. J.Journal of Physiology 2005 ;566(Pt 2):341-353

Cardiac function in hearts isolated from a rat model deficient in mast cells.Kennedy,R. H.; Hauer-Jensen,M.; Joseph,J.American Journal of Physiology - Heart & Circulatory Physiology 2005 ;288(2):H632-7

Protective role of mast cells in homocysteine-induced cardiac remodeling.Joseph,J.; Kennedy,R. H.; Devi,S.; Wang,J.; Joseph,L.; Hauer-Jensen,M.American Journal of Physiology - Heart & Circulatory Physiology 2005 ;288(5):H2541-5

Hyperhomocysteinaemia-induced atrial remodelling in hypertensive rats.Joseph,J.; Washington,A.; Joseph,L.; Kennedy,R. H.Clinical & Experimental Pharmacology & Physiology 2004 ;31(5-6):331-337

Acute negative inotropic effects of homocysteine are mediated via the endothelium.Kennedy,R. H.; Owings,R.; Shekhawat,N.; Joseph,J.American Journal of Physiology - Heart & Circulatory Physiology 2004 ;287(2):H812-7

Vasodilatory effects of cholinergic agonists are greatly diminished in aorta from M3R-/- mice.Khurana,S.; Chacon,I.; Xie,G.; Yamada,M.; Wess,J.; Raufman,J. P.; Kennedy,R. H.European journal of pharmacology 2004 ;493(1-3):127-132

JAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytesYu,X.; Kennedy,R. H.; Liu,S. J.The Journal of biological chemistry 2003 ;278(18):16304-16309

Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive ratsJoseph,J.; Joseph,L.; Shekhawat,N. S.; Devi,S.; Wang,J.; Melchert,R. B.; Hauer-Jensen,M.; Kennedy,R. H.American journal of physiology.Heart and circulatory physiology 2003 ;285(2):H679-86

Sex differences in L-type calcium current after chronic ethanol consumption in ratsKennedy,R. H.; Liu,S. J.Toxicology and applied pharmacology 2003 ;189(3):196-203

Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influxLiu,S. J.; Kennedy,R. H.American journal of physiology.Heart and circulatory physiology 2003 ;285(2):H735-44

Alterations in Ca2+ cycling by lysoplasmenylcholine in adult rabbit ventricular myocytesLiu,S. J.; Kennedy,R. H.; Creer,M. H.; McHowat,J.American journal of physiology.Cell physiology 2003 ;284(4):C826-38

The stimulation of tumor necrosis factor and inhibition of glucose transport and lipoprotein lipase in adipose cells by 2,3,7,8-tetrachlorodibenzo-p-dioxinKern,P. A.; Dicker-Brown,A.; Said,S. T.; Kennedy,R. H.; Fonseca,V. A.Metabolism: clinical and experimental 2002 ;51(1):65-68

Linoleic acid metabolites act to increase contractility in isolated rat heartMitchell,L. A.; Grant,D. F.; Melchert,R. B.; Petty,N. M.; Kennedy,R. H.CARDIOVASCULAR TOXICOLOGY 2002 ;2(3):219-230

Effects of gender on the cardiac toxicity elicited by chronic ethanol intake in ratsKennedy,R. H.; Stewart,C.; Light,K. E.; Wyeth,R. P.Toxicology and applied pharmacology 2002 ;179(2):111-118

Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonistCheng,K.; Khurana,S.; Chen,Y.; Kennedy,R. H.; Zimniak,P.; Raufman,J. P.The Journal of pharmacology and experimental therapeutics 2002 ;303(1):29-35

Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive ratsJoseph,J.; Washington,A.; Joseph,L.; Koehler,L.; Fink,L. M.; Hauer-Jensen,M.; Kennedy,R. H.American journal of physiology.Heart and circulatory physiology 2002 ;283(6):H2567-74

Lovastatin inhibits phenylephrine-induced ERK activation and growth of cardiacMelchert,R. B.; Liu,H.; Granberry,M. C.; Kennedy,R. H.CARDIOVASCULAR TOXICOLOGY 2001 ;1(3):237-252

Doxorubicin affects the cardiac muscarinic system in the ratChugun,A.; Uchide,T.; Temma,K.; Kennedy,R. H.; Klimberg,S. V.; Hara,Y.; Sasaki,T.; Akera,T.The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2001 ;63(12):1315-1322

Aging-associated changes in whole cell K(+) and L-type Ca(2+) currents in rat ventricular myocytesLiu,S. J.; Wyeth,R. P.; Melchert,R. B.; Kennedy,R. H.American journal of physiology.Heart and circulatory physiology 2000 ;279(3):H889-900

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with hyperinsulinemia and insulin resistanceCranmer,M.; Louie,S.; Kennedy,R. H.; Kern,P. A.; Fonseca,V. A.Toxicological sciences : an official journal of the Society of Toxicology 2000 ;56(2):431-436

Induction of Ca-independent PLA(2) and conservation of plasmalogen polyunsaturated fatty acids in diabetic heartMcHowat,J.; Creer,M. H.; Hicks,K. K.; Jones,J. H.; McCrory,R.; Kennedy,R. H.American journal of physiology.Endocrinology and metabolism 2000 ;279(1):E25-32

  • Fishing
  • Jogging