Wendy Kartje
  • Professor
  • Division Director, Neuroscience Research/CVRI
  • Molecular Pharmacology and Therapeutics
Research Summary

Current Interests: Neuronal plasticity and recovery of function after stroke and spinal cord injury

The overall goal of our research program is to use translational approaches to improve functional recovery after neural injury by enhancing neuronal plasticity, i.e. the ability of the intact part of the brain to take over for the damaged area. This laboratory uses the rodent focal ischemic model to investigate recovery after stroke, or the drop-weight method of injury to investigate mechanisms of recovery after spinal cord injury. A variety of methods to enhance neural plasticity and repair are tested, i.e. blockade of the major neurite growth inhibitory protein Nogo-A, pharmacologic methods paired with rehabilitation, and adult human bone marrow stem cell treatment. Functional outcome is then assessed using a battery of behavioral tests and outcome is correlated with anatomical tracing to determine axonal plasticity of spared neuronal pathways, dendritic plasticity using the golgi-cox method, or electrophysiological methods to directly stimulate and map new neuronal connections.

View a partial list of target=_blank>Dr. Kartjie's publications through the National Library of Medicine's PubMed online database.


Evidence for Fibroblast Growth Factor-2 as a Mediator of Amphetamine-Enhanced Motor Improvement following StrokeWolf,W. A.; Martin,J. L.; Kartje,G. L.; Farrer,R. G.PLoS ONE 2014 ;9(9):e108031

Kinematic Analysis of Motor Recovery With Human Adult Bone Marrow–Derived Somatic Cell Therapy in a Rat Model of StrokeBraun,R. G.; Andrews,E. M.; Kartje,G. L.Neurorehabilitation & Neural Repair 2012 ;26(7):898-906

Delayed anti-nogo-a therapy improves function after chronic stroke in adult rats.Tsai,S. Y.; Papadopoulos,C. M.; Schwab,M. E.; Kartje,G. L.Stroke 2011 ;42(1):186-190

Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes.Sarkey,J. P.; Chu,M.; McShane,M.; Bovo,E.; Mou,Y. A.; Zima,A. V.; de Tombe,P. P.; Kartje,G. L.; Martin,J. L.Journal of Molecular & Cellular Cardiology 2011 ;50(6):1044-1055

Dendritic spine alterations in neocortical pyramidal neurons following postnatal neuronal Nogo-A knockdownPradhan,A. D.; Case,A. M.; Farrer,R. G.; Tsai,S. Y.; Cheatwood,J. L.; Martin,J. L.; Kartje,G. L.Developmental neuroscience 2010 ;32(4):313-320

Cognitive recovery in the aged rat after stroke and anti-Nogo-A immunotherapy.Gillani,R. L.; Tsai,S. Y.; Wallace,D. G.; O'Brien,T. E.; Arhebamen,E.; Tole,M.; Schwab,M. E.; Kartje,G. L.Behavioural brain research 2010 ;208(2):415-424

Long-term motor improvement after stroke is enhanced by short-term treatment with the alpha-2 antagonist, atipamezole.Beltran,E. J.; Papadopoulos,C. M.; Tsai,S. Y.; Kartje,G. L.; Wolf,W. A.Brain research 2010 ;1346( ):174-182

Motor recovery and axonal plasticity with short-term amphetamine after strokePapadopoulos,C. M.; Tsai,S. Y.; Guillen,V.; Ortega,J.; Kartje,G. L.; Wolf,W. A.Stroke 2009 ;40(1):294-302

Quantification of synaptic density in corticostriatal projections from rat medial agranular cortexReep,R. L.; Wu,J. H.; Cheatwood,J. L.; Corwin,J. V.; Kartje,G. L.; Mir,A.Brain research 2008 ;1233( ):27-34

Human adult bone marrow-derived somatic cell therapy results in functional recovery and axonal plasticity following stroke in the rat.Andrews,E. M.; Tsai,S. Y.; Johnson,S. C.; Farrer,J. R.; Wagner,J. P.; Kopen,G. C.; Kartje,G. L.Experimental neurology 2008 ;211(2):588-592

Neuronal plasticity and functional recovery after ischemic strokeCheatwood,J. L.; Emerick,A. J.; Kartje,G. L.Topics in Stroke Rehabilitation 2008 ;15(1):42-50

Nogo-A expression after focal ischemic stroke in the adult rat.Cheatwood,J. L.; Emerick,A. J.; Schwab,M. E.; Kartje,G. L.Stroke 2008 ;39(7):2091-2098

Nogo-A inhibition induces recovery from neglect in ratsBrenneman,M. M.; Wagner,S. J.; Cheatwood,J. L.; Heldt,S. A.; Corwin,J. V.; Reep,R. L.; Kartje,G. L.; Mir,A. K.; Schwab,M. E.Behavioural brain research 2008 ;187(2):262-272

Intrathecal treatment with anti-Nogo-A antibody improves functional recovery in adult rats after stroke.Tsai,S. Y.; Markus,T. M.; Andrews,E. M.; Cheatwood,J. L.; Emerick,A. J.; Mir,A. K.; Schwab,M. E.; Kartje,G. L.Experimental Brain Research 2007 ;182(2):261-266

Dendritic plasticity in the adult rat following middle cerebral artery occlusion and Nogo-a neutralization.Papadopoulos,C. M.; Tsai,S. Y.; Cheatwood,J. L.; Bollnow,M. R.; Kolb,B. E.; Schwab,M. E.; Kartje,G. L.Cerebral Cortex 2006 ;16(4):529-536

Visual cortical plasticity following unilateral sensorimotor cortical lesions in the neonatal rat.Papathanasiou,E. S.; Peachey,N. S.; Goto,Y.; Neafsey,E. J.; Castro,A. J.; Kartje,G. L.Experimental neurology 2006 ;199(1):122-129

Axonal plasticity is associated with motor recovery following amphetamine treatment combined with rehabilitation after brain injury in the adult ratRamic,M.; Emerick,A. J.; Bollnow,M. R.; O'Brien,T. E.; Tsai,S. Y.; Kartje,G. L.Brain research 2006 ;1111(1):176-186

Delayed treatment with monoclonal antibody IN-1 1 week after stroke results in recovery of function and corticorubral plasticity in adult rats.Seymour,A. B.; Andrews,E. M.; Tsai,S. Y.; Markus,T. M.; Bollnow,M. R.; Brenneman,M. M.; O'Brien,T. E.; Castro,A. J.; Schwab,M. E.; Kartje,G. L.Journal of Cerebral Blood Flow & Metabolism 2005 ;25(10):1366-1375

Experimental diabetes attenuates cerebral cortical-evoked forelimb motor responses.Emerick,A. J.; Richards,M. P.; Kartje,G. L.; Neafsey,E. J.; Stubbs,E. B.,JrDiabetes 2005 ;54(9):2764-2771

Recovery and brain reorganization after stroke in adult and aged rats.Markus,T. M.; Tsai,S. Y.; Bollnow,M. R.; Farrer,R. G.; O'Brien,T. E.; Kindler-Baumann,D. R.; Rausch,M.; Rudin,M.; Wiessner,C.; Mir,A. K.; Schwab,M. E.; Kartje,G. L.Annals of Neurology 2005 ;58(6):950-953

Behavioral recovery and anatomical plasticity in adult rats after cortical lesion and treatment with monoclonal antibody IN-1Emerick,A. J.; Kartje,G. L.Behavioural brain research 2004 ;152(9):315-325

Functional reorganization of the motor cortex in adult rats after cortical lesion and treatment with monoclonal antibody IN-1.Emerick,A. J.; Neafsey,E. J.; Schwab,M. E.; Kartje,G. L.Journal of Neuroscience 2003 ;23(12):4826-4830

Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN-1 antibody treatment in the adult ratPapadopoulos,C. M.; Tsai,S-Y; Alsbiei,T.; O'Brien,T. E.; Schwab,M. E.; Kartje,G. L.Annals of Neurology 2002 ;51(4):433-441

Compensatory sprouting and impulse rerouting after unilateral pyramidal tract lesion in neonatal ratsZ'Graggen,W. J.; Fouad,K.; Raineteau,O.; Metz,G. A.; Schwab,M. E.; Kartje,G. L.The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 ;20(17):6561-6569

Medical School
  • Loyola University Chicago Stritch School of Medicine
  • Loyola University Medical Center, Neurology