Zhiyong Mi
  • Assistant Professor
  • Surgical Research

Osteopontin mediates an MZF1-TGF-beta1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancerWeber,C. E.; Kothari,A. N.; Wai,P. Y.; Li,N. Y.; Driver,J.; Zapf,M. A.; Franzen,C. A.; Gupta,G. N.; Osipo,C.; Zlobin,A.; Syn,W. K.; Zhang,J.; Kuo,P. C.; Mi,Z.Oncogene 2014 ; ( ):

Novel clinical therapeutics targeting the epithelial to mesenchymal transitionKothari,A. N.; Mi,Z.; Zapf,M.; Kuo,P. C.Clinical and translational medicine 2014 ;3( ):35-014-0035-0. eCollection 2014

Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4a transcriptional activityGuo,H.; Gao,C.; Mi,Z.; Wai,P. Y.; Kuo,P. C.The Biochemical journal 2014 ;461(2):347

Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in miceCoombes,J. D.; Swiderska-Syn,M.; Dolle,L.; Reid,D.; Eksteen,B.; Claridge,L.; Briones-Orta,M. A.; Shetty,S.; Oo,Y. H.; Riva,A.; Chokshi,S.; Papa,S.; Mi,Z.; Kuo,P. C.; Williams,R.; Canbay,A.; Adams,D. H.; Diehl,A. M.; van Grunsven,L. A.; Choi,S. S.; Syn,W. K.Gut 2014 ; ( ):

Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replicationChoi,S. S.; Claridge,L. C.; Jhaveri,R.; Swiderska-Syn,M.; Clark,P.; Suzuki,A.; Pereira,T. A.; Mi,Z.; Kuo,P. C.; Guy,C. D.; Pereira,F. E.; Diehl,A. M.; Patel,K.; Syn,W. K.Clinical science (London, England : 1979) 2014 ;126(12):845-855

Osteopontin Up-Regulates Critical Epithelial-Mesenchymal Transition Transcription Factors to Induce an Aggressive Breast Cancer PhenotypeLi,N. Y.; Weber,C. E.; Mi,Z.; Wai,P. Y.; Cuevas,B. D.; Kuo,P. C.Journal of the American College of Surgeons 2013 ; ( ):

An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell linesLi,N. Y.; Weber,C. E.; Wai,P. Y.; Cuevas,B. D.; Zhang,J.; Kuo,P. C.; Mi,Z.Surgery 2013 ;154(2):404-410

Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft modelBhattacharya,S. D.; Mi,Z.; Kim,V. M.; Guo,H.; Talbot,L. J.; Kuo,P. C.Annals of Surgery 2012 ;255(2):319-325

Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markersBhattacharya,S. D.; Mi,Z.; Talbot,L. J.; Guo,H.; Kuo,P. C.Surgery 2012 ;152(3):449-454

EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells.Zhang,J.; Guo,H.; Mi,Z.; Gao,C.; Bhattacharya,S.; Li,J.; Kuo,P. C.Experimental cell research 2009 ;315(2):304-312

Identification of osteopontin-dependent signaling pathways in a mouse model of human breast cancerMi,Z.; Guo,H.; Kuo,P. C.BMC research notes 2009 ;2( ):119-0500-2-119

RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells.Mi,Z.; Guo,H.; Russell,M. B.; Liu,Y.; Sullenger,B. A.; Kuo,P. C.Molecular Therapy: the Journal of the American Society of Gene Therapy 2009 ;17(1):153-161

PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymesYang,Q.; Larsen,S. K.; Mi,Z.; Robbins,P. D.; Basse,P. H.The AAPS journal 2008 ;10(4):614-621

Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene.Guo,H.; Mi,Z.; Kuo,P. C.Journal of Biological Chemistry 2008 ;283(37):25209-25217

Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis.Guo,H.; Wai,P. Y.; Mi,Z.; Gao,C.; Zhang,J.; Kuo,P. C.Surgery 2008 ;144(2):182-188

Induction of an effective anti-tumor immune response and tumor regression by combined administration of IL-18 and ApoptinLian,H.; Jin,N.; Li,X.; Mi,Z.; Zhang,J.; Sun,L.; Li,X.; Zheng,H.; Li,P.Cancer immunology, immunotherapy : CII 2007 ;56(2):181-192

Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages.Guo,L.; Guo,H.; Gao,C.; Mi,Z.; Russell,W. B.; Kuo,P. C.Surgery 2007 ;142(2):156-162

Characterization of the PC4 binding domain and its interactions with HNF4alpha.Guo,H.; Gao,C.; Mi,Z.; Zhang,J.; Kuo,P. C.Journal of Biochemistry 2007 ;141(5):635-640

Targeting of products of genes to tumor sites using adoptively transferred A-NK and T-LAK cellsGoding,S.; Yang,Q.; Mi,Z.; Robbins,P. D.; Basse,P. H.CANCER GENE THERAPY 2007 ;14(5):441-450

Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages.Gao,C.; Guo,H.; Mi,Z.; Grusby,M. J.; Kuo,P. C.Journal of Immunology 2007 ;178(3):1870-1881

Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.Gao,C.; Mi,Z.; Guo,H.; Kuo,P. C.Neoplasia (New York) 2007 ;9(9):699-706

Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells.Mi,Z.; Oliver,T.; Guo,H.; Gao,C.; Kuo,P. C.Cancer research 2007 ;67(9):4088-4097

Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells.Takami,Y.; Russell,M. B.; Gao,C.; Mi,Z.; Guo,H.; Mantyh,C. R.; Kuo,P. C.Surgery 2007 ;142(2):163-169

Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells.Mi,Z.; Guo,H.; Wai,P. Y.; Gao,C.; Kuo,P. C.Carcinogenesis 2006 ;27(6):1134-1145

Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritisKeravala,A.; Lechman,E. R.; Nash,J.; Mi,Z.; Robbins,P. D.ARTHRITIS RESEARCH & THERAPY 2006 ;8(4):R91

Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritisYao,Q.; Seol,D. W.; Mi,Z.; Robbins,P. D.ARTHRITIS RESEARCH & THERAPY 2006 ;8(1):R16

Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells.Wai,P. Y.; Mi,Z.; Gao,C.; Guo,H.; Marroquin,C.; Kuo,P. C.Journal of Biological Chemistry 2006 ;281(28):18973-18982

Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation.Wai,P. Y.; Guo,L.; Gao,C.; Mi,Z.; Guo,H.; Kuo,P. C.Surgery 2006 ;140(2):132-140

Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.Guo,H.; Gao,C.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Biochemical Journal 2006 ;394(Pt 2):379-387

Antitumor research on human laryngeal carcinoma with combined application of VP3 gene, IL-18 gene and HN geneGuan,G.; Jin,N.; Mi,Z.; Li,X.; Lian,H.; Jin,C.; Sun,L.; Wen,L.Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of clinical otorhinolaryngology 2005 ;19(15):704-706

Construction of the nucleic vaccine pVVP3L-18HN and its antitumor effect on human laryngeal carcinomaGuan,G. F.; Jin,N. Y.; Mi,Z. Q.; Li,X.; Lian,H.; Jin,C. S.; Sun,L. L.; Wen,L. J.Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 2005 ;40(8):566-570

Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis.Wai,P. Y.; Mi,Z.; Guo,H.; Sarraf-Yazdi,S.; Gao,C.; Wei,J.; Marroquin,C. E.; Clary,B.; Kuo,P. C.Carcinogenesis 2005 ;26(4):741-751

Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritisKim,S. H.; Lechman,E. R.; Bianco,N.; Menon,R.; Keravala,A.; Nash,J.; Mi,Z.; Watkins,S. C.; Gambotto,A.; Robbins,P. D.Journal of immunology (Baltimore, Md.: 1950) 2005 ;174(10):6440-6448

Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages.Gao,C.; Guo,H.; Wei,J.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Nitric Oxide 2005 ;12(2):121-126

Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin.Gao,C.; Guo,H.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Journal of Immunology 2005 ;175(1):523-530

A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line.Gao,C.; Mi,Z.; Guo,H.; Wei,J.; Wai,P. Y.; Kuo,P. C.Biochemical & Biophysical Research Communications 2004 ;321(4):1010-1016

S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages.Gao,C.; Guo,H.; Wei,J.; Mi,Z.; Wai,P.; Kuo,P. C.Journal of Biological Chemistry 2004 ;279(12):11236-11243

Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.Mi,Z.; Guo,H.; Wai,P. Y.; Gao,C.; Wei,J.; Kuo,P. C.Journal of Biological Chemistry 2004 ;279(45):46659-46667

Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptideRehman,K. K.; Bertera,S.; Bottino,R.; Balamurugan,A. N.; Mai,J. C.; Mi,Z.; Trucco,M.; Robbins,P. D.The Journal of biological chemistry 2003 ;278(11):9862-9868

The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigenLechman,E. R.; Keravala,A.; Nash,J.; Kim,S. H.; Mi,Z.; Robbins,P. D.Gene therapy 2003 ;10(24):2029-2035

Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor IGiannoukakis,N.; Mi,Z.; Rudert,W. A.; Gambotto,A.; Trucco,M.; Robbins,P.Gene therapy 2000 ;7(23):2015-2022