Clodia Osipo, PhD | Loyola Medicine

Clodia Osipo, PhD

Cancer Biology

Associate Professor

Languages Spoken

English, Persian,Assyrian

Clinical Expertise

Biography

Interests
Family and Friends;Tennis;Swimming

Medical Education

Medical School
Residency
Fellowship

Board Certification

Research

  • DAXX-inducing phytoestrogens inhibit ER+ tumor initiating cells and delay tumor development. Peiffer, DS; Ma, E; Wyatt, D; Albain, KS; Osipo, C, NPJ breast cancer
  • DAXX Suppresses Tumor-Initiating Cells in Estrogen Receptor-Positive Breast Cancer Following Endocrine Therapy. Peiffer, DS; Wyatt, D; Zlobin, A; Piracha, A; Ng, J; Dingwall, AK; Albain, KS; Osipo, C, Cancer research
  • Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer Fukushiro-Lopes, D. F.; Hegel, A. D.; Rao, V.; Wyatt, D.; Baker, A.; Breuer, E. K.; Osipo, C.; Zartman, J. J.; Burnette, M.; Kaja, S.; Kouzoukas, D. E.; Burris, S.; Jones, W. K.; Gentile, S.
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  • Inhibition of HER2 Increases JAGGED1-dependent Breast Cancer Stem Cells: Role for Membrane JAGGED1. Shah, D; Wyatt, D; Baker, AT; Simms, P; Peiffer, DS; Fernandez, M; Rakha, E; Green, A; Filipovic, A; Miele, L; Osipo, C, Clinical cancer research : an official journal of the American Association for Cancer Research
  • Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival. Baker, A; Wyatt, D; Bocchetta, M; Li, J; Filipovic, A; Green, A; Peiffer, DS; Fuqua, S; Miele, L; Albain, KS; Osipo, C, Oncogene
  • Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation Sobol, A.; Askonas, C.; Alani, S.; Weber, M. J.; Ananthanarayanan, V.; Osipo, C.; Bocchetta, M., Molecular cancer research : MCR
  • Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer Fukushiro-Lopes, D. F.; Hegel, A. D.; Rao, V.; Wyatt, D.; Baker, A.; Breuer, E. K.; Osipo, C.; Zartman, J. J.; Burnette, M.; Kaja, S.; Kouzoukas, D.; Burris, S.; Jones, W. K.; Gentile, S., Oncotarget
  • The role of Rak in the regulation of stability and function of BRCA1. Kim, JL; Ha, GH; Campo, L; Denning, MF; Patel, TB; Osipo, C; Lin, SY; Breuer, EK, Oncotarget
  • ATG9A loss confers resistance to trastuzumab via c-Cbl mediated Her2 degradation Nunes, J.; Zhang, H.; Angelopoulos, N.; Chhetri, J.; Osipo, C.; Grothey, A.; Stebbing, J.; Giamas, G., Oncotarget
  • Cancer stem cells and HER2 positive breast cancer: The story so far. Shah, D; Osipo, C, Genes & diseases
  • Human Epidermal Growth Factor Receptor 2 (HER2) Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival Das, S.; Sondarva, G.; Viswakarma, N.; Nair, R. S.; Osipo, C.; Tzivion, G.; Rana, B.; Rana, A., The Journal of biological chemistry
  • PKCalpha Attenuates Jagged-1-Mediated Notch Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance Pandya, K.; Wyatt, D.; Gallagher, B.; Shah, D.; Baker, A.; Bloodworth, J.; Zlobin, A.; Pannuti, A.; Green, A.; Ellis, I. O.; Filipovic, A.; Sagert, J.; Rana, A.; Albain, K. S.; Miele, L.; Denning, M. F.; Osipo, C., Clinical cancer research : an official journal of the American Association for Cancer Research
  • The role of Rak in the regulation of stability and function of BRCA1 Kim, J. L.; Ha, G. H.; Campo, L.; Denning, M. F.; Patel, T. B.; Osipo, C.; Lin, S. Y.; Breuer, E. K., Oncotarget
  • Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer Baker, A. T.; Zlobin, A.; Osipo, C., Frontiers in oncology
  • Osteopontin mediates an MZF1-TGF-beta1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer Weber, C. E.; Kothari, A. N.; Wai, P. Y.; Li, N. Y.; Driver, J.; Zapf, M. A.; Franzen, C. A.; Gupta, G. N.; Osipo, C.; Zlobin, A.; Syn, W. K.; Zhang, J.; Kuo, P. C.; Mi, Z., Oncogene
  • Crosstalk between PKCalpha and Notch-4 in endocrine-resistant breast cancer cells Yun, J.; Pannuti, A.; Espinoza, I.; Zhu, H.; Hicks, C.; Zhu, X.; Caskey, M.; Rizzo, P.; D'Souza, G.; Backus, K.; Denning, M. F.; Coon, J.; Sun, M.; Bresnick, E. H.; Osipo, C.; Wu, J.; Strack, P. R.; Tonetti, D. A.; Miele, L., Oncogenesis
  • Evaluation of biomarkers in multifocal/multicentric invasive breast carcinomas Pekmezci, M.; Szpaderska, A.; Osipo, C.; Ersahin, C., International Journal of Surgical Pathology
  • Gamma secretase inhibitors of Notch signaling Olsauskas-Kuprys, R.; Zlobin, A.; Osipo, C., OncoTargets and therapy
  • The functional role of notch signaling in triple-negative breast cancer Speiser, J. J.; Ersahin, C.; Osipo, C., Vitamins and hormones
  • The Effect of Cold Ischemia Time and/or Formalin Fixation on Estrogen Receptor Progesterone Receptor, and Human Epidermal Growth Factor Receptor-2 Results in Breast Carcinoma, Pekmezci, M.; Szpaderska, A.; Osipo, C.; Ersahin, C., Pathology research international
  • NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications Clementz, A. G.; Rogowski, A.; Pandya, K.; Miele, L.; Osipo, C., Breast cancer research : BCR
  • Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence. Pandya, K.; Meeke, K.; Clementz, A. G.; Rogowski, A.; Roberts, J.; Miele, L.; Albain, K. S.; Osipo, C., British journal of cancer
  • Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Hao, L.; Rizzo, P.; Osipo, C.; Pannuti, A.; Wyatt, D.; Cheung, L. W.; Sonenshein, G.; Osborne, B. A.; Miele, L., Oncogene
  • Targeting Notch signaling cross-talk with estrogen receptor and ErbB-2 in breast cancer Rizzo, P.; Osipo, C.; Pannuti, A.; Golde, T.; Osborne, B.; Miele, L., Advances in Enzyme Regulation
  • Trastuzumab resistance: role for Notch signaling Mehta, K.; Osipo, C., Thescientificworldjournal
  • Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches Rizzo, P.; Miao, H.; D'Souza, G.; Osipo, C.; Song, L. L.; Yun, J.; Zhao, H.; Mascarenhas, J.; Wyatt, D.; Antico, G.; Hao, L.; Yao, K.; Rajan, P.; Hicks, C.; Siziopikou, K.; Selvaggi, S.; Bashir, A.; Bhandari, D.; Marchese, A.; Lendahl, U.; Qin, J. Z.; Tonetti, D. A.; Albain, K.; Nickoloff, B. J.; Miele, L., Cancer research
  • ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. Osipo, C.; Patel, P.; Rizzo, P.; Clementz, A. G.; Hao, L.; Golde, T. E.; Miele, L., Oncogene
  • Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Osipo, C.; Golde, T. E.; Osborne, B. A.; Miele, L. A., Laboratory Investigation
  • Rational targeting of Notch signaling in cancer Rizzo, P.; Osipo, C.; Foreman, K. E.; Golde, T.; Osborne, B.; Miele, L., Oncogene
  • Intracellular distribution of TiO2-DNA oligonucleotide nanoconjugates directed to nucleolus and mitochondria indicates sequence specificity Paunesku, T.; Vogt, S.; Lai, B.; Maser, J.; Stojicevic, N.; Thurn, K. T.; Osipo, C.; Liu, H.; Legnini, D.; Wang, Z.; Lee, C.; Woloschak, G. E., Nano letters
  • Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer. Osipo, C.; Meeke, K.; Cheng, D.; Weichel, A.; Bertucci, A.; Liu, H.; Jordan, V. C., International journal of oncology
  • Cooperative effect of gefitinib and fumitremorgin c on cell growth and chemosensitivity in estrogen receptor alpha negative fulvestrant-resistant MCF-7 cells Liu, H.; Cheng, D.; Weichel, A. K.; Osipo, C.; Wing, L. K.; Chen, B.; Louis, T. E.; Jordan, V. C., International journal of oncology
  • Hedgehog signaling in hepatocellular carcinoma: novel therapeutic strategy targeting hedgehog signaling in HCC Osipo, C.; Miele, L., Cancer Biology & Therapy
  • Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal Lewis, J. S.; Osipo, C.; Meeke, K.; Jordan, V. C., The Journal of steroid biochemistry and molecular biology
  • MCT-1 oncogene contributes to increased in vivo tumorigenicity of MCF7 cells by promotion of angiogenesis and inhibition of apoptosis Levenson, A. S.; Thurn, K. E.; Simons, L. A.; Veliceasa, D.; Jarrett, J.; Osipo, C.; Jordan, V. C.; Volpert, O. V.; Satcher, R. L., Jr; Gartenhaus, R. B., Cancer research
  • Reversal of tamoxifen resistant breast cancer by low dose estrogen therapy Osipo, C.; Gajdos, C.; Cheng, D.; Jordan, V. C., The Journal of steroid biochemistry and molecular biology
  • Trastuzumab therapy for tamoxifen-stimulated endometrial cancer Osipo, C.; Meeke, K.; Liu, H.; Cheng, D.; Lim, S.; Weichel, A.; Jordan, V. C., Cancer research
  • The consequences of exhaustive antiestrogen therapy in breast cancer: estrogen-induced tumor cell death Osipo, C.; Liu, H.; Meeke, K.; Jordan, V. C., Experimental biology and medicine (Maywood, N.J.)
  • Apoptotic action of 17beta-estradiol in raloxifene-resistant MCF-7 cells in vitro and in vivo Liu, H.; Lee, E. S.; Gajdos, C.; Pearce, S. T.; Chen, B.; Osipo, C.; Loweth, J.; McKian, K.; De Los Reyes, A.; Wing, L.; Jordan, V. C., Journal of the National Cancer Institute
  • Changing role of the oestrogen receptor in the life and death of breast cancer cells Jordan, V. C.; Osipo, C.; Schafer, J. M.; Fox, J. E.; Cheng, D.; Liu, H., Breast (Edinburgh, Scotland)
  • Paradoxical action of fulvestrant in estradiol-induced regression of tamoxifen-stimulated breast cancer Osipo, C.; Gajdos, C.; Liu, H.; Chen, B.; Jordan, V. C., Journal of the National Cancer Institute
  • Loss of insulin-like growth factor II receptor expression promotes growth in cancer by increasing intracellular signaling from both IGF-I and insulin receptors Osipo, C.; Dorman, S.; Frankfater, A., Experimental cell research