Nephrologist: Karen Griffin, MD, FACP | Loyola Medicine

Karen Griffin, MD

Karen Griffin, MD, FACP

Medicine

Nephrology
Professor
Fellowship Program Director, Nephrology,Medical Director, LUHS Comprehensive Hypertension Program

Languages Spoken

English

Clinical Expertise

About Dr. Griffin

Biography

Dr. Griffin is a Professor of Medicine (Nephrology) at the Stritch School of Medicine, Loyola University and Renal Section Chief at the Edward Hines, Jr. V.A. Dr. Griffin received her medical degree from Rush University in Chicago, and subsequently completed her internal medicine residency and clinical/research fellowship in nephrology at Rush. As a clinician, she is primarily focused on hypertension and kidney disease and has been director of the Loyola University American Heart Association’s Designated Comprehensive Hypertension Center and has been recognized as a U.S. News and World Reports Top Doctor. Her research focus has been on the role of hypertension on the progression of chronic kidney disease and the impact of altered hemodynamics in the development and progression of diabetic and obesity-related nephropathies. She has received research funding from the NIH and Merit Review and published more than 80 articles, invited reviews and book chapters. Dr. Griffin has served as chair of the Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development Services of the Scientific Merit Review Board; the VA Merit Review Renal Study Section; and National Kidney Foundation of Illinois, Research committees. Additionally, she has served as a reviewer for several NIH study sections and been a member of several editorial boards and associate-editor of the ASN Nephrology Self-Assessment Program. She is currently Chair of the American Heart Association’s Council on Hypertension and Guest Editor of the journal Hypertension. She has served as a member of the American Society of Nephrology’s Hypertension Advisory Group. Dr. Griffin is a recipient of the American Medical Women's Association Awards for Leadership and Academic Excellence, The Student’s Choice Award at the Medical College of Wisconsin, the Arthur C. Corcoran Memorial Lecture of the American Heart Association Hypertension Council, and the Lois T. Ellison Lecture of the Medical College of Georgia.

Interests
Bicycling, Exercise, Gardening, Fishing

Medical Education

Medical School
Rush Medical College of Rush University
Residency
Rush-Presbyterian-St. Luke's Medical Center - Internal Medicine: General
Fellowship
  • Rush-Presbyterian-St. Luke's Medical Center - Internal Medicine: Nephrology

Board Certification

American Board of Internal Medicine
American Board of Internal Medicine Subspecialty Nephrology

Research

  • Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease Griffin, K. A., Hypertension (Dallas, Tex.: 1979)
  • Non-dialysis dependent chronic kidney disease is associated with high total and out-of-pocket healthcare expenditures Small, C.; Kramer, H. J.; Griffin, K. A.; Vellanki, K.; Leehey, D. J.; Bansal, V. K.; Markossian, T. W., BMC Nephrology
  • Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy Polichnowski, A. J.; Licea-Vargas, H.; Picken, M. M.; Long, J.; Bisla, R.; Williamson, G. A.; Bidani, A. K.; Griffin, K. A., American journal of physiology.Renal physiology
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  • Hemodynamic basis for the limited renal injury in rats with angiotensin II-induced hypertension Polichnowski, A. J.; Griffin, K. A.; Picken, M. M.; Licea-Vargas, H.; Long, J.; Williamson, G. A.; Bidani, A. K., American journal of physiology.Renal physiology
  • Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model Griffin, K. A.; Polichnowski, A.; Litbarg, N.; Picken, M.; Venkatachalam, M. A.; Bidani, A. K., Hypertension
  • Severe renal mass reduction impairs recovery and promotes fibrosis after AKI Polichnowski, A. J.; Lan, R.; Geng, H.; Griffin, K. A.; Venkatachalam, M. A.; Bidani, A. K., Journal of the American Society of Nephrology : JASN
  • Blood pressure-renal blood flow relationships in conscious angiotensin II- and phenylephrine-infused rats Polichnowski, A. J.; Griffin, K. A.; Long, J.; Williamson, G. A.; Bidani, A. K., American journal of physiology.Renal physiology
  • Renal microvascular dysfunction hypertension and CKD progression, Bidani, A. K.; Polichnowski, A. J.; Loutzenhiser, R.; Griffin, K. A., CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
  • Large BP-dependent and -independent differences in susceptibility to nephropathy after nitric oxide inhibition in Sprague-Dawley rats from two major suppliers. Griffin, K.; Polichnowski, A.; Licea-Vargas, H.; Picken, M.; Long, J.; Williamson, G.; Bidani, A., American Journal of Physiology - Renal Physiology
  • Large Bp-Dependent and -Independent Differences in Susceptibility to Nephropathy After Nitric Oxide Inhibition in Sprague-Dawley Rats from Two Major Suppliers Griffin, K. A.; Polichnowski, A. J.; Licea-Vargas, H.; Picken, M.; Long, J.; Williamson, G. A.; Bidani, A. K., American journal of physiology.Renal physiology
  • Solute and water excretion patterns in patients with nocturnal polyuria Herek, J. I.; FitzGerald, M. P.; Mohindra, M.; Wickman, C.; Leehey, D. J.; Bidani, A. K.; Griffin, K. A., International Journal of Nephrology & Urology
  • Angiotensin II type 2 receptor in chronic kidney disease: the good side of angiotensin II?. Griffin, K. A.; Bidani, A. K., Kidney international
  • Protective importance of the myogenic response in the renal circulation Bidani, A. K.; Griffin, K. A.; Williamson, G.; Wang, X.; Loutzenhiser, R., Hypertension
  • Adverse renal consequences of obesity Griffin, K. A.; Kramer, H.; Bidani, A. K., American Journal of Physiology - Renal Physiology
  • Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Pravenec, M.; Churchill, P. C.; Churchill, M. C.; Viklicky, O.; Kazdova, L.; Aitman, T. J.; Petretto, E.; Hubner, N.; Wallace, C. A.; Zimdahl, H.; Zidek, V.; Landa, V.; Dunbar, J.; Bidani, A. K.; Griffin, K.; Qi, N.; Maxova, M.; Kren, V.; Mlejnek, P.; Wang, J.; Kurtz, T. W., Nature genetics
  • Potential Risks of Calcium Channel Blockers in Chronic Kidney Disease. Griffin, K. A.; Bidani, A. K., Current Cardiology Reports
  • Systolic and mean blood pressures and afferent arteriolar myogenic response dynamics: a modeling approach. Williamson, G. A.; Loutzenhiser, R.; Wang, X.; Griffin, K. A.; Bidani, A. K., American Journal of Physiology.Regulatory, Integrative and Comparative Physiology
  • Dynamic blood pressure load and nephropathy in the ZSF1 (fa/fa cp) model of type 2 diabetes. Griffin, K. A.; Abu-Naser, M.; Abu-Amarah, I.; Picken, M. M.; Williamson, G. A.; Bidani, A. K., American Journal of Physiology - Renal Physiology
  • Spontaneously reduced blood pressure load in the rat streptozotocin-induced diabetes model: potential pathogenetic relevance. Bidani, A. K.; Picken, M. M.; Hacioglu, R.; Williamson, G.; Griffin, K. A., American Journal of Physiology - Renal Physiology
  • Characterization of dynamics in renal autoregulation using volterra models. Hacioglu, R.; Williamson, G. A.; Abu-Amarah, I.; Griffin, K. A.; Bidani, A. K., IEEE Transactions on Biomedical Engineering
  • Hypertension and kidney damage. Griffin, K. A., Journal of clinical hypertension
  • Progression of renal disease: renoprotective specificity of renin-angiotensin system blockade Griffin, K. A.; Bidani, A. K., Clinical Journal of The American Society of Nephrology: CJASN
  • Renal autoregulation: new perspectives regarding the protective and regulatory roles of the underlying mechanisms Loutzenhiser, R.; Griffin, K.; Williamson, G.; Bidani, A. K., American Journal of Physiology - Regulatory Integrative & Comparative Physiology
  • Systolic blood pressure as the trigger for the renal myogenic response: protective or autoregulatory? Loutzenhiser, R.; Griffin, K. A.; Bidani, A. K., Current Opinion in Nephrology & Hypertension
  • The benefits of renin-angiotensin blockade in hypertension are dependent on blood-pressure lowering. Bidani, A. K.; Griffin, K. A., Nature Clinical Practice Nephrology
  • Differential effects of salt on renal hemodynamics and potential pressure transmission in stroke-prone and stroke-resistant spontaneously hypertensive rats. Abu-Amarah, I.; Bidani, A. K.; Hacioglu, R.; Williamson, G. A.; Griffin, K. A., American Journal of Physiology - Renal Physiology
  • Recommendations for blood pressure measurement in animals: summary of an AHA scientific statement from the Council on High Blood Pressure Research Professional and Public Education Subcommittee, Kurtz, T. W.; Griffin, K. A.; Bidani, A. K.; Davisson, R. L.; Hall, J. E., Arteriosclerosis, Thrombosis & Vascular Biology
  • Recommendations for blood pressure measurement in humans and experimental animals. Part 2: Blood pressure measurement in experimental animals: a statement for professionals from the subcommittee of professional and public education of the American Heart Association council on high blood pressure research Kurtz, T. W.; Griffin, K. A.; Bidani, A. K.; Davisson, R. L.; Hall, J. E., Hypertension
  • Blood pressure lability and glomerulosclerosis after normotensive 5/6 renal mass reduction in the rat. Griffin, K. A.; Picken, M. M.; Bidani, A. K., Kidney international
  • Effects of calcium channel blockers on "dynamic" and "steady-state step" renal autoregulation. Griffin, K. A.; Hacioglu, R.; Abu-Amarah, I.; Loutzenhiser, R.; Williamson, G. A.; Bidani, A. K., American Journal of Physiology - Renal Physiology
  • Hypertensive renal damage: insights from animal models and clinical relevance Griffin, K. A.; Bidani, A. K., Current hypertension reports
  • Pathophysiology of hypertensive renal damage: implications for therapy Bidani, A. K.; Griffin, K. A., Hypertension
  • "Step" vs. "dynamic" autoregulation: implications for susceptibility to hypertensive injury. Bidani, A. K.; Hacioglu, R.; Abu-Amarah, I.; Williamson, G. A.; Loutzenhiser, R.; Griffin, K. A., American Journal of Physiology - Renal Physiology
  • Long-term blood-pressure monitoring in unrestrained animals. Griffin, K. A.; Abu-Amarah, I.; Bidani, A. K., Methods in Molecular Medicine
  • Low protein diet mediated renoprotection in remnant kidneys: Renal autoregulatory versus hypertrophic mechanisms. Griffin, K. A.; Picken, M. M.; Giobbie-Hurder, A.; Bidani, A. K., Kidney international
  • Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependent Griffin, K. A.; Abu-Amarah, I.; Picken, M. M.; Bidani, A. K., Hypertension
  • Increased genetic susceptibility to renal damage in the stroke-prone spontaneously hypertensive rat. Churchill, P. C.; Churchill, M. C.; Griffin, K. A.; Picken, M. M.; Webb, R. C.; Kurtz, T. W.; Bidani, A. K., Kidney international
  • Long-term renal consequences of hypertension for normal and diseased kidneys Bidani, A. K.; Griffin, K. A., Current Opinion in Nephrology & Hypertension
  • Comparative effects of selective T- and L-type calcium channel blockers in the remnant kidney model. Griffin, K. A.; Picken, M. M.; Bakris, G. L.; Bidani, A. K., Hypertension
  • Differential salt-sensitivity in the pathogenesis of renal damage in SHR and stroke prone SHR. Griffin, K. A.; Churchill, P. C.; Picken, M. M.; Webb, R. C.; Kurtz, T. W.; Bidani, A. K., American Journal of Hypertension
  • Genetic susceptibility to renal injury in hypertension Bidani, A. K.; Griffin, K. A.; Churchill, P. C.; Churchill, M. C.; St Lezin, E.; Kurtz, T. W., Experimental nephrology
  • Relative antihypertensive and glomeruloprotective efficacies of enalapril and candesartan cilexetil in the remnant kidney model. Griffin, K. A.; Picken, M. M.; Bakris, G.; Bidani, A. K., Journal of Renin-Angiotensin-Aldosterone System
  • Functional and structural correlates of glomerulosclerosis after renal mass reduction in the rat. Griffin, K. A.; Picken, M. M.; Churchill, M.; Churchill, P.; Bidani, A. K., Journal of the American Society of Nephrology
  • Lack of evidence of blood pressure-independent protection by renin-angiotensin system blockade after renal ablation Bidani, A. K.; Griffin, K. A.; Bakris, G.; Picken, M. M., Kidney international