Loyola Medicine Hosts Heart Disease Workshop on Giant Proteins
Tuesday, June 21, 2016

Loyola Hosting Workshop on Giant Proteins Linked to Heart Disease

Loyola University Medical Center

MAYWOOD, IL – Loyola University Chicago is hosting a June 22 workshop on three giant proteins that play critical roles in heart disease.

The conference will be held in the new state-of-the-art Center for Translational Research and Education on Loyola’s Health Sciences Campus in Maywood, Illinois. Panel members and speakers will range from researchers just beginning in the field to senior scientists known worldwide for their research.

The conference, which is open to the media, is titled “Titin and its binding partners, myosin binding protein-C and obscurin in health and disease.”

Titin is an essential component of muscle. It’s the largest protein in the body, weighing about 15 times as much as an average protein. In the heart, it acts like a spring, affecting the heart’s ability to contract and relax. Normally when people age, the titin protein gets shorter. But in heart failure patients, the protein grows longer and becomes less effective.

Myosin binding protein C (MyBP-C) is critical for the normal functioning of striated muscles, including heart muscles. During a heart attack, cardiac MyBP-C breaks into pieces. This fragmentation coincides with damage to heart muscle and heart failure.
Obscurin is a muscle protein that’s related to titin.

The workshop is organized by Sakthivel Sadayappan, PhD, MBA, associate professor in the department of cell and molecular physiology of Loyola University Chicago; Aikaterini Kontrogianni-Konstantopoulos, PhD, associate professor, University of Maryland; and Henk Granzier, PhD, professor, University of Arizona. 

About Loyola Medicine and Trinity Health

Loyola Medicine, a member of Trinity Health, is a quaternary care system based in the western suburbs of Chicago that includes Loyola University Medical Center (LUMC), Gottlieb Memorial Hospital, MacNeal Hospital and convenient locations offering primary and specialty care services from 1,877 physicians throughout Cook, Will and DuPage counties. LUMC is a 547-licensed-bed hospital in Maywood that includes the William G. and Mary A. Ryan Center for Heart & Vascular Medicine, the Cardinal Bernardin Cancer Center, a Level 1 trauma center, Illinois's largest burn center, a certified comprehensive stroke center and a children’s hospital. Having delivered compassionate care for over 50 years, Loyola also trains the next generation of caregivers through its teaching affiliation with Loyola University Chicago’s Stritch School of Medicine and Marcella Niehoff School of Nursing. Gottlieb is a 247-licensed-bed community hospital in Melrose Park with 150 physician offices, an adult day care program, the Gottlieb Center for Fitness, the Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park. MacNeal Hospital is a 374-bed teaching hospital in Berwyn with advanced inpatient and outpatient medical, surgical and psychiatric services, advanced diagnostics and treatments. MacNeal has a 12-bed acute rehabilitation unit, a 25-bed inpatient skilled nursing facility, and a 68-bed behavioral health program and community clinics. MacNeal has provided quality, patient-centered care to the near west suburbs since 1919.

Trinity Health is one of the largest multi-institutional Catholic healthcare systems in the nation, serving diverse communities that include more than 30 million people across 22 states. Trinity Health includes 92 hospitals, as well as 109 continuing care locations that include PACE programs, senior living facilities and home care and hospice services. Its continuing care programs provide nearly 2.5 million visits annually. Based in Livonia, Mich., and with annual operating revenues of $18.3 billion and assets of $26.2 billion, the organization returns $1.1 billion to its communities annually in the form of charity care and other community benefit programs. Trinity employs about 129,000 colleagues, including 7,800 employed physicians and clinicians. Committed to those who are poor and underserved in its communities, Trinity is known for its focus on the country's aging population. As a single, unified ministry, the organization is the innovator of Senior Emergency Departments, the largest not-for-profit provider of home health care services—ranked by number of visits—in the nation, as well as the nation’s leading provider of PACE (Program of All Inclusive Care for the Elderly) based on the number of available programs.