Maurizio Bocchetta
  • Associate Professor
  • Pathology
  • Molecular Pharmacology and Therapeutics
Research Summary

Our research is focused on studying and fighting hypoxic tumor microenvironment

Primary research interests involve the following: mechanisms of malignant transformation caused by oncogenic DNA viruses, interaction of the major Simian Virus 40 (SV40) oncogenes with cellular proteins, pathogenesis of mesothelioma.


Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary studyPievani,M.; Bocchetta,M.; Boccardi,M.; Cavedo,E.; Bonetti,M.; Thompson,P. M.; Frisoni,G. B.Neurobiology of aging 2013 ;34(7):1728-1739

Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairmentClerx,L.; van Rossum,I. A.; Burns,L.; Knol,D. L.; Scheltens,P.; Verhey,F.; Aalten,P.; Lapuerta,P.; van de Pol,L.; van Schijndel,R.; de Jong,R.; Barkhof,F.; Wolz,R.; Rueckert,D.; Bocchetta,M.; Tsolaki,M.; Nobili,F.; Wahlund,L. O.; Minthon,L.; Frolich,L.; Hampel,H.; Soininen,H.; Visser,P. J.Neurobiology of aging 2013 ;34(8):2003-2013

Atypical nucleus accumbens morphology in psychopathy: another limbic piece in the puzzleBoccardi,M.; Bocchetta,M.; Aronen,H. J.; Repo-Tiihonen,E.; Vaurio,O.; Thompson,P. M.; Tiihonen,J.; Frisoni,G. B.International journal of law and psychiatry 2013 ;36(2):157-167

Operationalizing protocol differences for EADC-ADNI manual hippocampal segmentationBoccardi,M.; Bocchetta,M.; Ganzola,R.; Robitaille,N.; Redolfi,A.; Duchesne,S.; Jack,C. R.,Jr; Frisoni,G. B.; EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging InitiativeAlzheimer's & dementia : the journal of the Alzheimer's Association 2013 ; ( ):

Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) MicroenvironmentLiang,S.; Galluzzo,P.; Sobol,A.; Skucha,S.; Rambo,B.; Bocchetta,M.Genes & cancer 2012 ;3(2):141-151

Notch signaling in lung cancerGalluzzo,P.; Bocchetta,M.Expert Review of Anticancer Therapy 2011 ;11(4):533-540

Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocolBoccardi,M.; Ganzola,R.; Bocchetta,M.; Pievani,M.; Redolfi,A.; Bartzokis,G.; Camicioli,R.; Csernansky,J. G.; de Leon,M. J.; deToledo-Morrell,L.; Killiany,R. J.; Lehericy,S.; Pantel,J.; Pruessner,J. C.; Soininen,H.; Watson,C.; Duchesne,S.; Jack,C. R.,Jr; Frisoni,G. B.Journal of Alzheimer's disease : JAD 2011 ;26 Suppl 3( ):61-75

Tissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular OncogenesZhang,L.; Qi,F.; Gaudino,G.; Strianese,O.; Yang,H.; Morris,P.; Pass,H. I.; Nerurkar,V. R.; Bocchetta,M.; Carbone,M.Genes & cancer 2010 ;1(10):1008-1020

Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway.Eliasz,S.; Liang,S.; Chen,Y.; De Marco,M. A.; Machek,O.; Skucha,S.; Miele,L.; Bocchetta,M.Oncogene 2010 ;29(17):2488-2498

SV40 Tag/p53 complexes actively promote malignant cell growth of human mesothelial cells.Bocchetta,M.; Carbone,M.Cellular Oncology 2008 ;30(5):455

The SV40 large T antigen-p53 complexes bind and activate the insulin-like growth factor-I promoter stimulating cell growth.Bocchetta,M.; Eliasz,S.; De Marco,M. A.; Rudzinski,J.; Zhang,L.; Carbone,M.Cancer research 2008 ;68(4):1022-1029

Opposite effects of Notch-1 and Notch-2 on mesothelioma cell survival under hypoxia are exerted through the Akt pathway.Graziani,I.; Eliasz,S.; De Marco,M. A.; Chen,Y.; Pass,H. I.; De May,R. M.; Strack,P. R.; Miele,L.; Bocchetta,M.Cancer research 2008 ;68(23):9678-9685

A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cells.Carbone,M.; Pannuti,A.; Zhang,L.; Testa,J. R.; Bocchetta,M.Cancer research 2008 ;68(22):9488-9496

Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung.Chen,Y.; De Marco,M. A.; Graziani,I.; Gazdar,A. F.; Strack,P. R.; Miele,L.; Bocchetta,M.Cancer research 2007 ;67(17):7954-7959

Polio vaccines, SV40 and human tumours, an update on false positive and false negative results.Elmishad,A. G.; Bocchetta,M.; Pass,H. I.; Carbone,M.Developments in biologicals 2006 ;123( ):109-117

TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis.Yang,H.; Bocchetta,M.; Kroczynska,B.; Elmishad,A. G.; Chen,Y.; Liu,Z.; Bubici,C.; Mossman,B. T.; Pass,H. I.; Testa,J. R.; Franzoso,G.; Carbone,M.Proceedings of the National Academy of Sciences of the United States of America 2006 ;103(27):10397-10402

Cellular and molecular parameters of mesotheliomaRamos-Nino,M. E.; Testa,J. R.; Altomare,D. A.; Pass,H. I.; Carbone,M.; Bocchetta,M.; Mossman,B. T.Journal of cellular biochemistry 2006 ;98(4):723-734

Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters.Kroczynska,B.; Cutrone,R.; Bocchetta,M.; Yang,H.; Elmishad,A. G.; Vacek,P.; Ramos-Nino,M.; Mossman,B. T.; Pass,H. I.; Carbone,M.Proceedings of the National Academy of Sciences of the United States of America 2006 ;103(38):14128-14133

Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961.Cutrone,R.; Lednicky,J.; Dunn,G.; Rizzo,P.; Bocchetta,M.; Chumakov,K.; Minor,P.; Carbone,M.Cancer research 2005 ;65(22):10273-10279

SV40 detection in human tumor specimensCarbone,M.; Rdzanek,M. A.; Rudzinski,J. J.; De Marco,M. A.; Bocchetta,M.; Ramos Nino,M.; Mossman,B.; Pass,H. I.Cancer research 2005 ;65(21):10120-10121

Epidemiology and molecular pathology at crossroads to establish causation: molecular mechanisms of malignant transformationBocchetta,M.; Carbone,M.Oncogene 2004 ;23(38):6484-6491

Genetically distant American Canine distemper virus lineages have recently caused epizootics with somewhat different characteristics in raccoons living around a large suburban zoo in the USA.Lednicky,J. A.; Dubach,J.; Kinsel,M. J.; Meehan,T. P.; Bocchetta,M.; Hungerford,L. L.; Sarich,N. A.; Witecki,K. E.; Braid,M. D.; Pedrak,C.; Houde,C. M.Virology Journal 2004 ;1( ):2

Evidence of an important role for SV40 in mesotheliomaPass,H. I.; Bocchetta,M.; Carbone,M.Thoracic Surgery Clinics 2004 ;14(4):489-495

SV40 and Notch-I: multi-functionality meets pleiotropyCarbone,M.; Bocchetta,M.Progress in Molecular & Subcellular Biology 2004 ;36( ):289-305

Advances in prophylactic cancer vaccine researchLe Poole,I. C.; Bommiasamy,H.; Bocchetta,M.; Kast,W. M.Expert Review of Anticancer Therapy 2003 ;3(4):537-545

Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells.Bocchetta,M.; Miele,L.; Pass,H. I.; Carbone,M.Oncogene 2003 ;22(1):81-89

SV40 and human brain tumorsCarbone,M.; Bocchetta,M.; Cristaudo,A.; Emri,S.; Gazdar,A.; Jasani,B.; Lednicky,J.; Miele,L.; Mutti,L.; Pass,H. I.; Ramael,M.; Rizzo,P.; Testa,J. R.; Weggen,S.; Yeung,A.International journal of cancer.Journal international du cancer 2003 ;106(1):140-2; author reply 143-5

Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation.Carbone,M.; Burck,C.; Rdzanek,M.; Rudzinski,J.; Cutrone,R.; Bocchetta,M.Cancer research 2003 ;63(19):6125-6129

New developments about the association of SV40 with human mesotheliomaCarbone,M.; Pass,H. I.; Miele,L.; Bocchetta,M.Oncogene 2003 ;22(33):5173-5180

High throughput testing of the SV40 Large T antigen binding to cellular p53 identifies putative drugs for the treatment of SV40-related cancers.Carbone,M.; Rudzinski,J.; Bocchetta,M.Virology 2003 ;315(2):409-414

Molecular analyses, morphology and immunohistochemistry together differentiate pleural synovial sarcomas from mesotheliomas: clinical implicationsCarbone,M.; Rizzo,P.; Powers,A.; Bocchetta,M.; Fresco,R.; Krausz,T.Anticancer Research 2002 ;22(6B):3443-3448

SV40 infection induces telomerase activity in human mesothelial cellsFoddis,R.; De Rienzo,A.; Broccoli,D.; Bocchetta,M.; Stekala,E.; Rizzo,P.; Tosolini,A.; Grobelny,J. V.; Jhanwar,S. C.; Pass,H. I.; Testa,J. R.; Carbone,M.Oncogene 2002 ;21(9):1434-1442

Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cellsToyooka,S.; Carbone,M.; Toyooka,K. O.; Bocchetta,M.; Shivapurkar,N.; Minna,J. D.; Gazdar,A. F.Oncogene 2002 ;21(27):4340-4344

SV40 and the pathogenesis of mesotheliomaRizzo,P.; Bocchetta,M.; Powers,A.; Foddis,R.; Stekala,E.; Pass,H. I.; Carbone,M.Seminars in cancer biology 2001 ;11(1):63-71

Interactions between 23S rRNA and tRNA in the ribosomal E siteBocchetta,M.; Xiong,L.; Shah,S.; Mankin,A. S.RNA (New York, N.Y.) 2001 ;7(1):54-63

Phylogenetic depth of the bacterial genera Aquifex and Thermotoga inferred from analysis of ribosomal protein, elongation factor, and RNA polymerase subunit sequencesBocchetta,M.; Gribaldo,S.; Sanangelantoni,A.; Cammarano,P.Journal of Molecular Evolution 2000 ;50(4):366-380

Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicityBocchetta,M.; Di Resta,I.; Powers,A.; Fresco,R.; Tosolini,A.; Testa,J. R.; Pass,H. I.; Rizzo,P.; Carbone,M.Proceedings of the National Academy of Sciences of the United States of America 2000 ;97(18):10214-10219

  • University of Illinois at Chicago Medical Center, Research