NCT00044967
Genetic Study of Young Patients With Colorectal Cancer
COMPLETED
NCT00044967
OBSERVATIONAL
A Prospective Study Of The Prognostic Significance Of Microsatellite Instability In Patients With Early Age-Of-Onset Colorectal Cancer
RATIONALE: Identifying gene mutations (microsatellite instability) may allow doctors to plan effective treatment for patients who develop colorectal cancer at an early age.
PURPOSE: Genetic trial to determine the significance of gene mutations in helping predict the outcome of treatment in patients who develop stage I, stage II, or stage III colorectal cancer at an early age.
DISEASE CHARACTERISTICS:
* Diagnosis of stage I-III adenocarcinoma of the colon or rectum
* Must have undergone an initial curative resection within the past year
* No colon or rectal cancer resection that does not allow for definitive T or N staging
* No initial post-surgical surveillance colonoscopy prior to study entry
* Must have a pathology specimen, with representative normal and tumor tissues, available for submission to the ACOSOG Central Specimen Bank prior to study entry
* No personal or family history of familial adenomatous polyposis
* No recurrent colorectal cancer
PATIENT CHARACTERISTICS:
Age
* 18 to 49 at first diagnosis
Other
* Must be willing to provide a family cancer history to the study team and continue with follow-up colonoscopic surveillance
* No other malignancy within the past 5 years except completely resected cervical cancer or nonmelanoma skin cancer
* No evidence of recurrence of other prior malignancy
PRIOR CONCURRENT THERAPY:
Radiotherapy
* No prior pelvic radiotherapy for rectal cancer
* No concurrent preoperative pelvic radiotherapy for rectal cancer
Surgery
* See Disease Characteristics
Colorectal Cancer
-
- Type: GENETIC
- Name: microsatellite instability analysis
- Description:
- Arm Group Labels: Group 1
- Alliance for Clinical Trials in Oncology