NCT03992352

Composite Health Assessment Risk Model (CHARM) for Older Adults (BMT CTN 1704)

Study Contact:

Study Phase:

Recruitment Status:

COMPLETED

NCT ID:

NCT03992352

Principal Investigator:

Study Type:

OBSERVATIONAL

Official Title:

Composite Health Assessment Risk Model (CHARM) for Older Adults: Applying Pre-Transplant Comorbidity, Geriatric Assessment, and BioMarkers on Non-Relapse Mortality After Allogeneic Transplant (BMT CTN 1704)

Summary

Prospective observational multicenter study of allogeneic Hematopoietic Stem Cell Transplantation (HCT) in recipients 60 years and older to assess important determinants of health status to be combined into a composite health risk model to improve risk assessment of non-relapse mortality (NRM).

Eligibility

Inclusion Criteria:

1. Subject is > 60.0 years old at time of enrollment.
2. Hematological malignancy as an indication for allogeneic transplantation.
3. Eligible for allogeneic transplantation based on institutional standards
4. First allogeneic transplant planned. Any conditioning regimen and allogeneic donor is acceptable.
5. Able to speak and read English. Spanish, and Mandarin will be acceptable when sites have ability to perform healthcare provider tests in those languages.
6. Written informed consent

Exclusion Criteria:

1. Prior allogeneic HCT

Disease(s) and\or Condition(s)

Hematologic Malignancy

Primary Purpose

Intervention/Treatment

- Type: DIAGNOSTIC_TEST
- Name: Age 60+ with planned HCT for Hematologic Malignancy
- Description: questionnaires, geriatric assessments
- Arm Group Labels: Age 60+ with planned HCT for Hematologic Malignancy

Sponsor

Center for International Blood and Marrow Transplant Research