Loyola University Medical Center

Gottlieb Memorial Hospital

MacNeal Hospital

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NCT05824832

Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery

Official Title:

Effects of a Triple Adjuvant Combination of Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery, a Prospective, Randomized Clinical Trial

Summary

The goal of this clinical trial is to learn if there is a difference in morphine requirements in patients after upper extremity surgeries including shoulder arthroscopy. The main question it aims to answer is whether there is a difference between Interscalene brachial plexus blocks with the addition of buprenorphine, dexamethasone, and clonidine and the same block without the adjuvant.

Eligibility

Inclusion Criteria:

* Patients ≥ 18 years old
* Patients undergoing shoulder arthroscopy
* Patients willing to participate and sign informed consent

Exclusion Criteria:

* Severe COPD/other contraindication to general anesthesia
* Patient with a weight of less than 60 kg
* Dementia, not alert or oriented to person, place, or time
* Chronic pain patient with daily opioid use at home.
* Patient with allergy to local anesthetics
* Patient refusal
* Total shoulder arthroplasty
* Concomitant pain in different area from operative site.
* Pregnancy
* Patient with active infection on the injection sites for the blocks
* Patients unable or willing to understand or comply with the study protocol

Disease(s) and\or Condition(s)

Pain, Postoperative

Primary Purpose
  • TREATMENT
Intervention/Treatment
    • Type: DRUG
    • Name: Interscalene block with the addition of buprenorphine, clonidine, dexamethasone
    • Description: Addition of the adjuvant buprenorphine, dexamethasone, and clonidine in the nerve block performed prior to shoulder arthroscopy surgery
    • Arm Group Labels: Interscalene block with the addition of buprenorphine, clonidine, dexamethasone
    • Type: DRUG
    • Name: Interscalene block with buprenorphine alone
    • Description: Addition of the adjuvant buprenorphine alone the in nerve block performed prior to shoulder arthroscopy surgery
    • Arm Group Labels: Interscalene block with buprenorphine alone
Sponsor
  • Loyola University