NCT00450281
S0424 - Carcinogens in Lung Tissue From Smokers (Closed to Entry as of 7/15/07) and Non-Smokers With Newly Diagnosed Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
COMPLETED
NCT00450281
OBSERVATIONAL
Molecular Epidemiology Case-Series Study of Non-Small Cell Lung Cancer in Smoking and Non-Smoking Women and Men
RATIONALE: Studying samples of blood and tissue from smokers (closed to entry as of 7/15/07) and non-smokers with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about risk factors for lung cancer and may help the study of cancer in the future.
PURPOSE: This clinical trial is studying carcinogens in lung tissue from smokers (closed to entry as of 7/15/07) and non-smokers with newly diagnosed stage I, stage II, or stage III non-small cell lung cancer.
DISEASE CHARACTERISTICS:
* Histologically confirmed non-small cell lung cancer
* Stage I, II, IIIA, or IIIB (T4 or N3) disease
* No malignant pleural effusion; if pleural fluid is present, 1 of the following criteria must be met:
* Benign pleural fluid
* Pleural fluid is due to prior thoracotomy
* Pleural fluid is deemed too small to safely tap
* No diagnosis by cytology alone
* Newly diagnosed disease
* Must have tumor blocks/slides available and must be willing to provide tissue samples
* Prior smoking history meeting 1 of the following criteria:
* Never smoker, defined as \< 100 cigarettes in lifetime
* Former smoker, defined as no smoking for ≥ 1 year
* Current smoker, defined as all others (closed to accrual as of 7/15/07)
* No pericardial effusions
PATIENT CHARACTERISTICS:
* No other prior malignancy except for 1 of the following:
* Adequately treated basal cell or squamous cell skin cancer
* In situ cervical cancer
* Other cancer for which the patient has been disease free for five years
PRIOR CONCURRENT THERAPY:
* No prior chemotherapy or radiotherapy
* Concurrent participation in therapeutic trials allowed
Lung Cancer
-
- Type: GENETIC
- Name: chromogenic in situ hybridization
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
-
- Type: GENETIC
- Name: gene expression analysis
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
-
- Type: GENETIC
- Name: mutation analysis
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
-
- Type: GENETIC
- Name: polymerase chain reaction
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
-
- Type: GENETIC
- Name: polymorphism analysis
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
-
- Type: OTHER
- Name: fluorescent antibody technique
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
-
- Type: OTHER
- Name: immunohistochemistry staining method
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
-
- Type: OTHER
- Name: laboratory biomarker analysis
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
-
- Type: OTHER
- Name: matrix-assisted laser desorption/ionization time of flight mass spectrometry
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
-
- Type: OTHER
- Name: study of socioeconomic and demographic variables
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
-
- Type: PROCEDURE
- Name: study of high risk factors
- Description:
- Arm Group Labels: Female, Ever-smokers, Female, Never-smokers, Male, Ever-smokers, Male, Never-smokers
- SWOG Cancer Research Network