Loyola Study Finds Liver Transplant Patients Have Higher Prevalence of Colon Cancer and Non-Hodgkin Lymphoma
January 9, 2019Categories: cancer, Digestive Health, Transplant
Tags: Cancer, Digestive Health, Transplant
MAYWOOD, IL – Liver transplant patients over time experience an increasing trend toward colon cancer and non-Hodgkin lymphoma, according to an award-winning study led by a Loyola Medicine gastroenterologist.
The study by Ayokunle Abegunde, MD, MSc, and colleagues also found that lung and heart transplant patients have a higher trend toward non-melanoma skin cancer.
Dr. Abegunde was the senior author of the study, presented during the American College of Gastroenterology annual conference in Philadelphia.
The study received a Presidential Poster Award in recognition of high-quality research that is unique and interesting. Fewer than 5% of accepted studies receive the award.
The immune-suppressing drugs that organ transplant recipients must take to prevent rejection put them at a higher risk for cancer. A weaker immune system is less able to attack cancer cells and makes a patient more vulnerable to infections from viruses that cause cancer.
Dr. Abegunde and colleagues examined records of 124,399 liver, heart and lung transplant patients in the National Inpatient Sample, the largest inpatient database in the United States. Sixty-seven percent were liver transplant recipients, 22% heart transplant recipients and 11% lung transplant recipients. The average age was 56, and 62% were male.
Post-transplant, 7.4% of heart transplant patients were diagnosed with cancer, compared with 6.3% in both liver and lung transplant patients.
Over time, there was an increasing trend in the prevalence of colon cancer and non-Hodgkin lymphoma in liver transplant recipients compared with lung and heart transplant recipients. There was an increasing trend in the prevalence of non-melanoma skin cancer among heart and lung transplant recipients compared with liver transplant recipients.
The results suggest that liver transplant patients may benefit from more frequent colonoscopy screenings for colon cancer and heart and lung transplant patients may benefit from more active screening for skin cancer, Dr. Abegunde said.
The study is the first to compare cancer trends among heart, lung and liver transplant patients using the National Inpatient Sample.
The study is titled, "Trends in Cancer Prevalence Among Liver, Heart and Lung Transplant Recipients in the United States, 2005 to 2014."
Dr. Abegunde is an assistant professor in the division of gastroenterology, department of Medicine of Loyola University Chicago Stritch School of Medicine.
Loyola's gastroenterology division is a national leader in colon cancer screening and is ranked 37th among nearly 5,000 in the nation by U.S. News & World Report.
In addition to Dr. Abegunde, other co-authors of the study are Chimezie Mbachi, MBBS, and Benjamin Mba, MD, of Stroger Hospital of Cook County; Setri Fugar, MD, of Rush University Medical Center; and Madhu Mathew, MD and Anthonia Ijeli, MD, of Cook County Health and Hospitals System.
About Loyola Medicine
Loyola Medicine, a member of Trinity Health, is a nationally ranked academic, quaternary care system based in Chicago's western suburbs. The three-hospital system includes Loyola University Medical Center (LUMC), Gottlieb Memorial Hospital, MacNeal Hospital, as well as convenient locations offering primary care, specialty care and immediate care services from nearly 2,000 physicians throughout Cook, Will and DuPage counties. LUMC is a 547-licensed-bed hospital in Maywood that includes the William G. and Mary A. Ryan Center for Heart & Vascular Medicine, the Cardinal Bernardin Cancer Center, the John L. Keeley, MD, Emergency Department, a Level 1 trauma center, Illinois's largest burn center, the Nancy W. Knowles Orthopaedic Institute, a certified comprehensive stroke center, transplant center and a children’s hospital. Having delivered compassionate care for over 50 years, Loyola also trains the next generation of caregivers through its academic affiliation with Loyola University Chicago’s Stritch School of Medicine and Marcella Niehoff School of Nursing.
For more information, visit loyolamedicine.org. You can also follow Loyola Medicine on LinkedIn, Facebook, Instagram or X (formerly known as Twitter).
About Trinity Health
Trinity Health is one of the largest not-for-profit, faith-based health care systems in the nation. It is a family of 127,000 colleagues and more than 38,300 physicians and clinicians caring for diverse communities across 26 states. Nationally recognized for care and experience, the Trinity Health system includes 93 hospitals, 107 continuing care locations, the second largest PACE program in the country, 142 urgent care locations and many other health and well-being services. In fiscal year 2024, the Livonia, Michigan-based health system invested $1.3 billion in its communities in the form of charity care and other community benefit programs. For more information, visit us at www.trinity-health.org, or follow us on LinkedIn, Facebook, and X (formerly known as Twitter).