NCT00257244
Inflammation and the Host Response to Injury (Burns)
COMPLETED
NCT00257244
OBSERVATIONAL
Inflammation and the Host Response to Injury
The purpose of this study is to help improve our understanding of the biology involved in the body's response to serious trauma or burn injury. The host response to trauma and burns is a collection of physiological and pathophysiological processes that depend critically upon the regulation of the human innate immune system, with particular emphasis on the inflammatory component of that system. No single research center or small group of centers has the capacity to delineate the integrated response of this complex biological system, which involves multiple molecular and genetic interactions that vary in time. Our proposal promotes the identification of important dynamic relationships that regulate the integration of this complex biological system, with the expectation that this understanding will ultimately impact the diagnosis, prognosis, and treatment of the hospitalized, severely injured patient.
Inclusion Criteria:
* Burn patients of all ages with 20% or greater of total body surface area burns that require surgical treatment
* Burn patients admitted to the burn unit within 96 hours (4 days) of burn injury
All patients meeting these criteria are entered into the epidemiologic database and assessed for specific exclusion criteria to establish whether serial blood draws are warranted.
Exclusion Criteria:
* Injury caused by chemical agent
* Deep injury caused by conduction of electrical current or charge
* Decision not to treat due to severity of injury
* Anoxic brain injury that is not expected to result in complete recovery
* Associated multiple injuries exclusive of burns (ISS >=25)
* Pre-morbid condition: Severe congestive heart failure (measured ejection fraction <20%)
* Pre-morbid condition: Malignancy currently under treatment
* Pre-morbid condition: Medical condition requiring systemic glucocorticoid treatment
* Pre-morbid condition: current systemic immunosuppression for organ transplant or chronic inflammatory condition
Trauma
Burns
Multiple Organ Failure
- Massachusetts General Hospital