NCT03714620
Sub-dissociative Dose Ketamine Dosing Study
PHASE4
COMPLETED
NCT03714620
INTERVENTIONAL
A Randomized, Controlled Trial of Intravenous Sub-dissociative Ketamine at Two Doses for Analgesia in the Emergency Department
Goal is to determine if in adults presenting to the Emergency Department (ED) with moderate to severe acute pain, Ketamine administered at 0.15 mg/kg will provide similar pain relief to Ketamine administered at 0.3 mg/kg, with fewer adverse effects.
Inclusion Criteria:
* Adults ages 18-59
* Weight 45 - 115 kg
* Acute abdominal, flank, back, musculoskeletal pain, or a headache
* Onset of pain within 7 days
* Pain score of 5 or more
* Requiring intravenous analgesia
* Hasn't been enrolled in this study previously
Exclusion Criteria:
* Pregnancy
* Breast-feeding
* Altered mental status rendering the patient unable to consent to the study
* Allergy to ketamine
* Unstable vital signs (systolic blood pressure <90 or >180 mm Hg, pulse rate <50 or >150 beats/minute, and respiration rate <10 or >30 breaths/minute)
* History of acute head or eye injury, seizure, intracranial hypertension
* Chronic pain
* Renal or hepatic insufficiency
* Known alcohol or drug use disorder
* Currently under influence of alcohol/opiates
* Acute psychiatric illness
Acute Pain
- TREATMENT
-
- Type: DRUG
- Name: Ketamine
- Description: Ketamine 0.15 mg/kg vs. 0.3 mg/kg IVPB over 15 minutes
- Arm Group Labels: 0.15 mg/kg IV Ketamine, 0.3 mg/kg IV Ketamine
- Loyola University